Losartan Impurity 61 CAS CATO-C4X-168361
| CAS No. | CATO-C4X-168361 |
| Molecular Formula | C22H23ClN4 |
| Molecular Weight | 378.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Losartan Impurity 61.
Losartan Impurity 61 (CAS CATO-C4X-168361) is a certified pharmaceutical impurity reference standard with the molecular formula C22H23ClN4 and a molecular weight of 378.90 g/mol.
Structurally, Losartan Impurity 61 (C22H23ClN4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 378.90 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H23ClN4 |
| Molecular Weight | 378.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Losartan Standards
- Losartan Impurity 15 (CAS 114772-55-3)
- Losartan Impurity 29 (CAS 2204369-11-7)
- Losartan Impurity 51 (CAS CATO-C4X-168351)
- Losartan Impurity 28 (CAS 124750-67-0)
- Losartan Impurity 57 (CAS C4X-13305)
- Losartan Impurity N2 (CAS 1351793-76-4)
- Losartan Impurity 37 (CAS CATO-C4X-168337)
- Losartan Impurity 49 (CAS CATO-C4X-168349)
Recommended Standards
- N-{[2-(4-Chlorophenyl)-4-methyl-1,3-thiazol-5-yl]methyl}benzenesulfonamide (CAS 865658-26-0)
- 1-(4-Bromo-3-iodophenyl)-2,2,2-trifluoroethan-1-one (CAS 1935411-18-9)
- N-(3-Chlorophenyl)-2-((4-ethyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 557752-85-9)
- 1-(3-Bromo-4-iodophenyl)-2,2,2-trifluoroethan-1-one (CAS 2149598-84-3)
- Lurbinectedin Impurity 23 (CAS 2248127-73-1)
- Entacapone impurity 52 (CAS CATO-C4X-162952)
- Iodixanol Impurity 15 (CAS CATO-C4X-166315)
- Methyl 2-((methoxycarbonothioyl)thio)acetate (CAS 123972-88-3)
- 5-Chloro-1,1-dioxo-isothiazol-3-one (CAS 1239320-63-8)
- 3-Amino-4-phenylthiophene-2-carbonitrile hydrochloride (CAS 1956377-73-3)
- Ethyl 6-chloro-4-methoxypicolinate (CAS 1122090-80-5)
- 6-Chloro-2-phenylpyridin-3-amine (CAS 111185-30-9)
- 2-Amino-3,3,3-trifluoro-2-methylpropanoic acid (CAS 422-23-1)
- Acetyl Dipeptide-1 (CAS 196604-48-5)
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