Olaparib Impurity 131 CAS CATO-C4X-1135131
| CAS No. | CATO-C4X-1135131 |
| Molecular Formula | C16H8FNO2 |
| Molecular Weight | 265.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Olaparib Impurity 131 (C16H8FNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Olaparib Impurity 131 (CAS CATO-C4X-1135131, C16H8FNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Olaparib Impurity 131 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H8FNO2 |
| Molecular Weight | 265.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Olaparib Standards
- Olaparib Impurity 132 (CAS CATO-C4X-1135132)
- Olaparib Impurity 133 (CAS CATO-C4X-1135133)
- Olaparib impurity 142 (CAS CATO-C4X-1135142)
- Olaparib Impurity 41 (CAS 763114-25-6)
- Olaparib Impurity 42 (CAS CATO-C4X-113542)
- Olaparib Impurity 130 (CAS CATO-C4X-1135130)
- Olaparib Impurity 19 (CAS CATO-C4X-113519)
- Olaparib Impurity 115 (CAS CATO-C4X-1135115)
Recommended Standards
- N-Dodecylquinolin-4-amine (CAS 58943-66-1)
- Mono(4-carboxybutyl) Phthalate (CAS 92569-48-7)
- Methyl (R)-3-fluoro-6-(1-hydroxyethyl)-5-(1H-pyrazol-1-yl)picolinate (CAS 2435611-69-9)
- Ethyl 8-fluoro-4-hydroxy-6-methoxyquinoline-3-carboxylate (CAS 851973-23-4)
- Cefotaxime Impurity 100 (CAS CATO-C4X-1201100)
- Agomelatine impurity 31 (CAS CATO-C4X-110831)
- Sofosbuvir Impurity 9 (CAS 2173637-26-6)
- 3-Nitrothiophene (CAS 822-84-4)
- Benserazide Impurity 21 (CAS 5625-41-2)
- Acetic acid, 2-methoxy-, sodium salt (CAS 50402-70-5)
- 4-(Quinolin-2-yl)aniline (CAS 22191-97-5)
- 5-Iodo-2-methoxypyridine (CAS 13472-61-2)
- Cyclohexanol (CAS 108-93-0)
- Semaglutide impurity 229 (CAS CATO-C4X-2226229)
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