Olaparib Impurity 132 CAS CATO-C4X-1135132
| CAS No. | CATO-C4X-1135132 |
| Molecular Formula | C16H8FNO2 |
| Molecular Weight | 265.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C16H8FNO2, Olaparib Impurity 132 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 265.24 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Olaparib Impurity 132 (CAS CATO-C4X-1135132, C16H8FNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H8FNO2 |
| Molecular Weight | 265.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Olaparib Standards
- Olaparib Impurity 131 (CAS CATO-C4X-1135131)
- Olaparib Impurity 133 (CAS CATO-C4X-1135133)
- Olaparib impurity 142 (CAS CATO-C4X-1135142)
- Olaparib Impurity 41 (CAS 763114-25-6)
- Olaparib Impurity 42 (CAS CATO-C4X-113542)
- Olaparib Impurity 130 (CAS CATO-C4X-1135130)
- Olaparib Impurity 19 (CAS CATO-C4X-113519)
- Olaparib Impurity 115 (CAS CATO-C4X-1135115)
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- (R)-tert-Butyl 3-(2-amino-4-fluorophenoxy)pyrrolidine-1-carboxylate (CAS 1233860-08-6)
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- 3-Fluoro-3-(4-fluorophenyl)pyrrolidine hydrochloride (CAS 1803589-76-5)
- 1-(1-Ethyl-1H-indol-3-yl)-3-(4-methylpyridin-2-yl)urea (CAS 941988-24-5)
- 4,4-Dimethyl-1,2,3,4-tetrahydroisoquinoline (CAS 78592-91-3)
- [D-His1]-Semaglutide (CAS CATO-C4X-2226127)
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