Olaparib Impurity 135 HCl CAS CATO-C4X-1135135
| CAS No. | CATO-C4X-1135135 |
| Molecular Formula | C16H14N4O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Olaparib Impurity 135 HCl (CAS CATO-C4X-1135135) is a certified pharmaceutical impurity reference standard with the molecular formula C16H14N4O3HCl and a molecular weight of 346.77 g/mol.
Olaparib Impurity 135 HCl (C16H14N4O3HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H14N4O3 HCl |
| Molecular Weight | 346.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Olaparib Standards
- Olaparib Impurity 69 (CAS 1007-16-5)
- Olaparib Impurity 24 (CAS 1021298-67-8)
- Olaparib Impurity 12 (CAS 1021298-68-9)
- Olaparib Impurity 88 (CAS 1062292-60-7)
- Olaparib Impurity 28 (CAS 1187479-72-6)
- Olaparib Impurity 134 (CAS 134435-16-8)
- Olaparib Impurity 93 (CAS 1379332-00-9)
- Olaparib Impurity 79 (CAS 13889-98-0)
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