Olaparib Impurity 12 CAS 1021298-68-9
| CAS No. | 1021298-68-9 |
| Molecular Formula | C16H10FN3O |
| Molecular Weight | 279.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Olaparib Impurity 12 (CAS 1021298-68-9, C16H10FN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Olaparib Impurity 12 (C16H10FN3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H10FN3O |
| Molecular Weight | 279.27 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Olaparib Standards
- Olaparib Impurity 109 (CAS CATO-C4X-1135109)
- Olaparib Impurity 14 (CAS 420846-72-6)
- Olaparib Impurity 44 (CAS CATO-C4X-113544)
- Olaparib Impurity 102 (CAS 1806327-68-3)
- Olaparib Impurity 105 (CAS 477535-39-0)
- Olaparib Impurity 93 (CAS 1379332-00-9)
- Olaparib Impurity 82 (CAS CATO-C4X-113582)
- Olaparib Impurity 58 (CAS CATO-C4X-113558)
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