Dapagliflozin Impurity 3 CAS CATO-C4X-11383
| CAS No. | CATO-C4X-11383 |
| Molecular Formula | C42H48Cl2O12 |
| Molecular Weight | 815.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Dapagliflozin Impurity 3 (C42H48Cl2O12) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Dapagliflozin Impurity 3 (CAS CATO-C4X-11383, C42H48Cl2O12) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C42H48Cl2O12 |
| Molecular Weight | 815.73 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 124 (CAS 2714814-62-5)
- Dapagliflozin Impurity 162 (CAS CATO-C4X-1138162)
- Dapagliflozin Impurity 170 (CAS CATO-C4X-1138170)
- Dapagliflozin impurity 221 (CAS CATO-C4X-1138221)
- Dapagliflozin Impurity 71 (CAS CATO-C4X-113871)
- Dapagliflozin Impurity 85 (CAS 2452300-79-5)
- Dapagliflozin Impurity 112 (CAS CATO-C4X-1138112)
- Dapagliflozin Impurity 192 (CAS CATO-C4X-1138192)
Recommended Standards
- N1,N1'-(1,3-phenylene)bis(2-chloro-N1,N3,N3-triphenylbenzene-1,3-diamine) (CAS 1800321-80-5)
- 680571-51-1 Kigamicin C (CAS 680571-51-1)
- Empagliflozin Impurity 309 (CAS CATO-C4X-1065309)
- (S)-1-(6-Benzamido-9H-purin-9-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite (CAS 851050-24-3)
- Thioctic acid Impurity 10 (CAS 188783-96-2)
- Drotaverin Impurity 70 (CAS CATO-C4X-243570)
- Phytomenadione/Vitamin K1 Impurity 124 (CAS CATO-C4X-2207124)
- 3,3'-Dioctyl-2,2'-bithiophene (CAS 138058-53-4)
- Ethyl 4-fluoro-7-methyl-1H-indole-2-carboxylate (CAS 1352906-36-5)
- 5-Chloro-2,3-difluoroisonicotinaldehyde (CAS 1333319-52-0)
- N-(5-Cyano-3-methyl-1-propyl-1H-pyrazol-4-yl)acetamide (CAS 89239-76-9)
- Swietenocoumarin B (CAS 64652-23-9)
- 3-Propyl-4,5-dihydroisoxazole-5-carbonitrile (CAS 190907-50-7)
- Insulin degludec (CAS 844439-96-9)
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