Dapagliflozin impurity 221 CAS CATO-C4X-1138221
| CAS No. | CATO-C4X-1138221 |
| Molecular Formula | C42H48Cl2O12 |
| Molecular Weight | 815.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Dapagliflozin impurity 221 (CAS CATO-C4X-1138221), a pharmacopoeial impurity reference standard (molecular formula C42H48Cl2O12, MW 815.73 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Dapagliflozin impurity 221 (C42H48Cl2O12) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 18.0, corresponding to approximately 18 ring(s) or double-bond equivalent(s). With a molecular weight of 815.73 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C42H48Cl2O12 |
| Molecular Weight | 815.73 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 124 (CAS 2714814-62-5)
- Dapagliflozin Impurity 162 (CAS CATO-C4X-1138162)
- Dapagliflozin Impurity 170 (CAS CATO-C4X-1138170)
- Dapagliflozin Impurity 3 (CAS CATO-C4X-11383)
- Dapagliflozin Impurity 71 (CAS CATO-C4X-113871)
- Dapagliflozin Impurity 85 (CAS 2452300-79-5)
- Dapagliflozin Impurity 112 (CAS CATO-C4X-1138112)
- Dapagliflozin Impurity 192 (CAS CATO-C4X-1138192)
Recommended Standards
- Empagliflozin Impurity 309 (CAS CATO-C4X-1065309)
- N1,N1'-(1,3-phenylene)bis(2-chloro-N1,N3,N3-triphenylbenzene-1,3-diamine) (CAS 1800321-80-5)
- Bizelesin (CAS 129655-21-6)
- 680571-51-1 Kigamicin C (CAS 680571-51-1)
- Eltrombopag Impurity 153 (CAS CATO-C4X-1198153)
- Ligagliptin impurity 107 (CAS CATO-C4X-1101107)
- Ampicillin EP Impurity H (CAS 73200-73-4)
- 6-(3-Chlorophenyl)-4-phenyl-2-(2-(piperidin-1-yl)ethyl)pyridazin-3(2H)-one (CAS 23348-28-9)
- 1-(Aminomethyl)-3-ethylcyclobutane-1-carboxylic acid (CAS 1487183-24-3)
- 4-Chloro-5-fluoro-2-(3-methoxy-2-methylphenoxy)-N-methylbenzamide (CAS 921213-28-7)
- Desmopressin Acetate (COLD SHIPMENT REQUIRED) (1173202) (CAS 62357-86-2)
- tert-butyl N-[6-(2-aminobutylamino)spiro[2.5]octan-2-yl]carbamate (CAS 2295296-91-0)
- 1-(3-Bromo-2-(trifluoromethyl)phenyl)-4,4-difluoropiperidine 1707367-58-5 (CAS 1707367-58-5)
- Semaglutide Impurity 129 (CAS 2490269-79-7)
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