Lenvatinib Impurity 157 CAS CATO-C4X-1140157
| CAS No. | CATO-C4X-1140157 |
| Molecular Formula | C21H17ClN6O6 |
| Molecular Weight | 484.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 484.85 g/mol gives Lenvatinib Impurity 157 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Lenvatinib Impurity 157 (CAS CATO-C4X-1140157) is a certified pharmaceutical impurity reference standard with the molecular formula C21H17ClN6O6 and a molecular weight of 484.85 g/mol.
Lenvatinib Impurity 157 (C21H17ClN6O6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H17ClN6O6 |
| Molecular Weight | 484.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Lenvatinib Standards
- Lenvatinib Impurity 52 (CAS CATO-C4X-114052)
- Lenvatinib Impurity 158 (CAS CATO-C4X-1140158)
- Lenvatinib Impurity 116 (CAS 417717-22-7)
- Lenvatinib Impurity 59 (CAS CATO-C4X-114059)
- Lenvatinib Impurity 31 (CAS 417722-95-3)
- Lenvatinib Impurity 145 (CAS CATO-C4X-1140145)
- Lenvatinib Impurity 184 (CAS 2412398-76-4)
- Lenvatinib Impurity 93 (CAS CATO-C4X-114093)
Recommended Standards
- 3,4,5-Triiodo-2,6-dimethylpyridine (CAS 98549-80-5)
- 3-{[(4-bromophenyl)methanesulfinyl]methyl}-5-{[(4-chlorophenyl)methyl]sulfanyl}-4-ethyl-4H-1,2,4-triazole (CAS 344275-16-7)
- 1,2-Ditetradecyl-sn-glycerol (CAS 36314-51-9)
- 5-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-3-(4-methoxyphenyl)-2-methyl-hexahydro-2H-pyrrolo[3,4-d][1,2]oxazole-4,6-dione (CAS 317833-31-1)
- Clevidipine butyrate Impurity 4 (CAS 188649-48-1)
- Vericiguat Impurity 90 (CAS CATO-C4X-289690)
- Mirogabalin Impurity 106 Benzenesulfonic Acid (CAS CATO-C4X-2924197)
- Ethyl N-((4-methoxyphenyl)sulfonyl)-N-(pyridin-2-yl)glycinate (CAS 860609-47-8)
- Furosemide Impurity 55 (CAS 76852-02-3)
- 2-tert-Butoxy-pyridine-4-carbaldehyde (CAS 1211519-23-1)
- 3,5-Diiodo-DL-tyrosine (CAS 66-02-4)
- Estradiol Valerate EP Impurity E (CAS 63042-28-4)
- Methyl 2-amino-2-(2-methoxyphenyl)acetate (CAS 77651-55-9)
- Semaglutide impurity 106 (CAS CATO-C4X-2226106)
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