Lenvatinib Impurity 116 CAS 417717-22-7
| CAS No. | 417717-22-7 |
| Molecular Formula | C24H23ClN4O4 |
| Molecular Weight | 466.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Lenvatinib Impurity 116.
Lenvatinib Impurity 116 (CAS 417717-22-7) is a certified pharmaceutical impurity reference standard with the molecular formula C24H23ClN4O4 and a molecular weight of 466.92 g/mol.
The molecular framework of Lenvatinib Impurity 116 (C24H23ClN4O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H23ClN4O4 |
| Molecular Weight | 466.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Lenvatinib Standards
- Lenvatinib Impurity 59 (CAS CATO-C4X-114059)
- Lenvatinib Impurity 31 (CAS 417722-95-3)
- Lenvatinib Impurity 155 (CAS CATO-C4X-1140155)
- Lenvatinib Impurity 156 (CAS CATO-C4X-1140156)
- Lenvatinib Impurity 52 (CAS CATO-C4X-114052)
- Lenvatinib Impurity 7 (CAS 2250242-56-7)
- Lenvatinib Impurity 157 (CAS CATO-C4X-1140157)
- Lenvatinib Impurity 66 (CAS CATO-C4X-114066)
Recommended Standards
- 6-[(2E)-2-{[(4-chlorophenyl)methoxy]imino}ethyl]-1-[2-(3,4-dimethoxyphenyl)ethyl]-4-oxo-1,4-dihydropyrimidine-5-carbonitrile (CAS 303148-52-9)
- Sunitinib Impurity 90 (CAS CATO-C4X-133390)
- Ertugliflozin impurity 64 (CAS CATO-C4X-301164)
- Suvorexant Impurity 45 (CAS 1030377-39-9)
- Benazepril EP Impurity A (CAS 131064-75-0)
- Lysine Impurity 40 (CAS CATO-C4X-221140)
- Neostigmine impurity 43 (CAS 2768847-25-0)
- Rimegepant Impurity 10 (CAS CATO-C4X-248710)
- 1,4,6,9-Tetramethyldibenzo[b,d]furan (CAS 62787-22-8)
- N-benzyl-6-chloro-N-methyl-2-(methylthio)pyrimidin-4-amine (CAS 478258-42-3)
- Indolin-6-ylboronic acid (CAS 1253912-15-0)
- 2-(2-((2,5-Dimethoxyphenyl)amino)thiazol-4-yl)-N-(2-methoxyethyl)acetamide (CAS 1040654-50-9)
- (R)-1-(2-Chloroimidazo[1,2-a]pyridin-3-yl)ethan-1-ol (CAS 1334160-92-7)
- Semaglutide impurity 270 (CAS CATO-C4X-2226270)
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