Alanyl Glutamine Impurity 1 CAS 159141-33-0
| CAS No. | 159141-33-0 |
| Molecular Formula | C8H13ClN2O4 |
| Molecular Weight | 236.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Alanyl Glutamine Impurity 1 (CAS 159141-33-0) is a certified pharmaceutical impurity reference standard with the molecular formula C8H13ClN2O4 and a molecular weight of 236.65 g/mol.
The molecular framework of Alanyl Glutamine Impurity 1 (C8H13ClN2O4) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Alanyl Glutamine Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H13ClN2O4 |
| Molecular Weight | 236.65 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Alanyl Standards
- Alanyl Glutamine Impurity 2 (CAS CATO-C4X-19742)
- Alanyl Glutamine Impurity 5 (CAS CATO-C4X-19745)
- Alanyl Glutamine Impurity 6 (CAS CATO-C4X-19746)
- DL-Alanyl-DL-phenylalanine (CAS 1999-45-7)
- Alanyl Glutamine Impurity 23 (CAS CATO-C4X-197423)
- Alanyl Glutamine Impurity 16 (CAS 672284-92-3)
- L-Alanyl-L-alanyl-L-alanine (CAS 5874-90-8)
- L-Alanyl-L-proline tert-Butyl Ester (CAS 29375-30-2)
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