Lenvatinib Impurity 177 CAS CATO-C4X-1140177
| CAS No. | CATO-C4X-1140177 |
| Molecular Formula | C20H17ClN4O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 449.29 g/mol gives Lenvatinib Impurity 177 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Lenvatinib Impurity 177 (CAS CATO-C4X-1140177, C20H17ClN4O4HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Lenvatinib Impurity 177 (C20H17ClN4O4HCl) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Lenvatinib Impurity 177 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H17ClN4O4 HCl |
| Molecular Weight | 449.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Lenvatinib Standards
- Lenvatinib Impurity 115 (CAS 106868-33-1)
- Lenvatinib Impurity 142 (CAS 1069122-99-1)
- Lenvatinib Impurity 48 (CAS 13021-02-8)
- Lenvatinib Impurity 71 (CAS 13066-95-0)
- Lenvatinib Impurity 93 (CAS 1378260-39-9)
- Lenvatinib Impurity N2 (CAS 13932-55-3)
- Lenvatinib Impurity 101 (CAS 1453-50-5)
- Lenvatinib Impurity 102 (CAS 15568-85-1)
Recommended Standards
- Atosiban Impurity 100 (CAS CATO-C4X-2293100)
- Rosuvastatin Impurity 251 (CAS 1416000-51-5)
- Avibactam Impurity Hcl (CAS 2891580-19-9)
- 6,8-Dichloro-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine (CAS 353258-21-6)
- Tert-butyl (1-(2-methylallyl)piperidin-4-yl)carbamate (CAS 1311656-51-5)
- 2-Chloro-1-(2,4,5-trimethyl-phenyl)-ethanone (CAS 62919-60-2)
- 2-(3-Fluorophenyl)-5-(methoxycarbonyl)-1-methyl-3-pyrrolidinecarboxylic acid (CAS 1219159-23-5)
- 4-(3-Fluorophenyl)butan-1-amine (CAS 1339855-93-4)
- 1-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol (CAS 40534-33-6)
- (Tyr9)-Cholecystokinin Octapeptide (sulfated) (H-9770.0005) (CAS 96607-61-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com