Aprepitant Impurity 81 CAS CATO-C4X-114181
| CAS No. | CATO-C4X-114181 |
| Molecular Formula | C26H22F7NO2 |
| Molecular Weight | 513.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Aprepitant Impurity 81 (CAS CATO-C4X-114181, C26H22F7NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C26H22F7NO2, Aprepitant Impurity 81 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 513.45 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Aprepitant Impurity 81 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C26H22F7NO2 |
| Molecular Weight | 513.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant Impurity 32 (CAS CATO-C4X-116832)
- Aprepitant impurity 55 (CAS CATO-C4X-114155)
- Aprepitant EP Impurity A (CAS 170729-76-7)
- Aprepitant Impurity 69 (CAS 178616-88-1)
- Aprepitant impurity 29 (CAS CATO-C4X-237929)
- Aprepitant Impurity 44 (CAS CATO-C4X-114144)
- Aprepitant impurity 56 (CAS CATO-C4X-114156)
- Aprepitant Impurity 13 (CAS 183664-56-4)
Recommended Standards
- N-(4-Chloro-2-methoxy-5-methylphenyl)-2-((5-(4-chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 476486-02-9)
- N-(2-Chloro-4,6-dimethylphenyl)-2-((4-(4-chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 476484-49-8)
- Dolutegravir Impurity 17 (CAS CATO-C4X-162017)
- (3R,3aS,9bS)-9b-((4-Fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[a]naphthalen-3-amine (CAS 2226318-82-5)
- Pemetrexed impurity 47 (CAS CATO-C4X-172647)
- Linezolid lmpurity 101 (CAS CATO-C4X-1073101)
- Pimavanserin Impurity 28 (CAS CATO-C4X-193828)
- Nevirapine 9-Chloro Impurity (CAS 1796928-56-7)
- 5-Bromo-4-ethylpyridin-2-ol (CAS 1369325-65-4)
- tert-Butyl 4,4-dimethoxy-3-oxopiperidine-1-carboxylate (CAS 1007595-82-5)
- 31-O-(Trimethylsilyl)rapamycin (CAS 331810-10-7)
- (3S,5s)-1,1-difluorospiro[2.3]Hexane-5-carboxylic acid (CAS 1773508-79-4)
- 3-Amino-N-cyclohexyl-4-methylbenzenesulfonamide (CAS 100800-56-4)
- Urotensin II-Related Peptide (human, mouse, rat) (CAS 342878-90-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com