Aprepitant Impurity 44 CAS CATO-C4X-114144
| CAS No. | CATO-C4X-114144 |
| Molecular Formula | C27H22F7NO2 |
| Molecular Weight | 525.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Aprepitant Impurity 44 (CAS CATO-C4X-114144) is a certified pharmaceutical impurity reference standard with the molecular formula C27H22F7NO2 and a molecular weight of 525.46 g/mol.
Based on its molecular formula C27H22F7NO2, Aprepitant Impurity 44 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 525.46 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Aprepitant Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H22F7NO2 |
| Molecular Weight | 525.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant impurity 56 (CAS CATO-C4X-114156)
- Aprepitant Impurity 13 (CAS 183664-56-4)
- Aprepitant impurity 29 (CAS CATO-C4X-237929)
- Aprepitant (CAS 170729-80-3)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant Impurity 3 (CAS 172822-28-5)
- Aprepitant Impurity 4 (CAS 172822-29-6)
Recommended Standards
- 4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-2,6-diiodophenol (CAS 923200-10-6)
- 1,4-Bis((4-chlorophenyl)thio)-5,8-dihydroxyanthracene-9,10-dione (CAS 90571-19-0)
- Aztreonam Impurity 93 (CAS CATO-C4X-152293)
- (5-((4-Bromophenyl)sulfonyl)-1-methyl-3-phenyl-1H-pyrazol-4-yl)methyl 2-methylbenzoate (CAS 318289-22-4)
- Urapidil Impurity 44 (CAS CATO-C4X-192444)
- Clarithromycin Impurity 23 (CAS 470-12-2)
- Metoclopramide Impurity 91 (CAS CATO-C4X-141591)
- 2-Hydroxy-3-(1H-indol-3-yl)butanoic acid (CAS 21193-78-2)
- 3,5-Dibromo-4-ethoxybenzaldehyde (CAS 381238-96-6)
- Lenvatinib Impurity 173 (CAS CATO-C4X-1140173)
- 1-Dehydroxy-1-Dehyro-Fexofenadine-d6 Methyl Ester (CAS 1795031-46-7)
- N-(5,7-Dimethylthiazolo[4,5-b]pyridin-2-yl)cyclohexanecarboxamide (CAS 1021078-63-6)
- 2,3-Dimethyl-2-pentene (CAS 10574-37-5)
- Liraglutide Impurity 19 TFA Salt (CAS CATO-C4X-199219)
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