Aprepitant Impurity 13 CAS 183664-56-4
| CAS No. | 183664-56-4 |
| Molecular Formula | C27H24F7NO2 |
| Molecular Weight | 527.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Aprepitant Impurity 13 (C27H24F7NO2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 527.47 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Aprepitant Impurity 13 (CAS 183664-56-4) is a certified pharmaceutical impurity reference standard with the molecular formula C27H24F7NO2 and a molecular weight of 527.47 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H24F7NO2 |
| Molecular Weight | 527.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant Impurity 44 (CAS CATO-C4X-114144)
- Aprepitant impurity 56 (CAS CATO-C4X-114156)
- Aprepitant impurity 29 (CAS CATO-C4X-237929)
- Aprepitant (CAS 170729-80-3)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant Impurity 3 (CAS 172822-28-5)
- Aprepitant Impurity 4 (CAS 172822-29-6)
Recommended Standards
- Sofosbuvir Impurity 92 (CAS CATO-C4X-105292)
- Fosaprepitant Impurity 53 (CAS 1254261-32-9)
- Bedaquiline Impurity 65 (Mixture of Enantiomers) (CAS CATO-C4X-116765)
- 2-Fluoro-4-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-[1,1-biphenyl]-4-methanol (CAS 1359164-11-6)
- Cinacalcet Impurity 42 (CAS CATO-C4X-105942)
- Elagolix Impurity 56 (CAS 102089-75-8)
- Lercanidipine Impurity 76 (CAS CATO-C4X-136476)
- (1R,2R)-2-(Benzylamino)cyclohexanol (CAS 141553-09-5)
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- tert-butyl 4-(aminomethyl)-2,2,5-trimethyl-1,3-oxazolidine-3-carboxylate (CAS 1315365-56-0)
- 1-(4-Chlorobenzyl)-1H-imidazole-2-carbaldehyde (CAS 1092302-43-6)
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- 1-Butyl-2,3-dimethyl-3-imidazolium Nitrate (CAS 922521-06-0)
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