Sitagliptin Impurity 100 CAS CATO-C4X-1144100
| CAS No. | CATO-C4X-1144100 |
| Molecular Formula | C16H15F6N5O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Sitagliptin Impurity 100 (CAS CATO-C4X-1144100) is a certified pharmaceutical impurity reference standard with the molecular formula C16H15F6N5OH3O4P and a molecular weight of 505.31 g/mol.
Sitagliptin Impurity 100 (C16H15F6N5OH3O4P) contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Sitagliptin Impurity 100 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H15F6N5O H3O4P |
| Molecular Weight | 505.31 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Sitagliptin Standards
- Sitagliptin Impurity 17 (CAS 1036273-20-7)
- Sitagliptin Impurity 966 (CAS 1151240-88-8)
- Sitagliptin Impurity 14 (CAS 1151240-91-3)
- Sitagliptin Impurity 12 HCl (CAS 1151240-91-3（free base）)
- Sitagliptin Impurity 77 (CAS 1152439-73-0)
- Sitagliptin Impurity 97 (CAS 1169707-29-2)
- Sitagliptin Tablets EP Impurity FP-E HCl (CAS 1204818-19-8)
- Sitagliptin Impurity 15 (CAS 1217809-78-3)
Recommended Standards
- Ketoconazole EP Impurity A (and enantiomer) HCI (CAS CATO-C4X-147228)
- Rivaroxaban Impurity 66 (CAS CATO-C4X-109066)
- Cefcapene Impurity 53 (CAS CATO-C4X-182453)
- 5-Hydroxy-2-isopropylpyrazolidine-1-carbaldehyde (CAS 124838-25-1)
- 3,5-Dibromo-4-n-butylbenzene (CAS 75894-94-9)
- (R,R)-BniPr-Sabox (CAS 880479-99-2)
- N-((tert-Butyldimethylsilyl)oxy)-4-methylbenzenesulfonamide (CAS 1028432-04-3)
- ABT-510 (acetate) (CAS 442526-87-6)
- 7-Oxo-6,7-dihydrothieno[2,3-c]pyridine-4-carbonitrile, 97% (CAS 912369-27-8)
- Semaglutide impurity 91 (CAS CATO-C4X-222691)
Why CATO?
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