Sitagliptin Impurity 17 CAS 1036273-20-7
| CAS No. | 1036273-20-7 |
| Molecular Formula | C9H7F3O2 |
| Molecular Weight | 204.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Sitagliptin Impurity 17.
Sitagliptin Impurity 17 (CAS 1036273-20-7) is a certified pharmaceutical impurity reference standard with the molecular formula C9H7F3O2 and a molecular weight of 204.15 g/mol.
Based on its molecular formula C9H7F3O2, Sitagliptin Impurity 17 contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 204.15 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Sitagliptin Impurity 17 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H7F3O2 |
| Molecular Weight | 204.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
Related Sitagliptin Standards
- Sitagliptin Impurity 81 (CAS 261952-27-6)
- Sitagliptin Impurity 125 (CAS 877402-45-4)
- Sitagliptin Impurity 117 (CAS 871035-61-9)
- Sitagliptin impurity 11 (CAS 764667-63-2)
- Sitagliptin Impurity 16 (CAS 849832-73-1)
- Sitagliptin Impurity 109 (CAS 936630-56-7)
- Sitagliptin Impurity 166 (CAS 2226094-64-8)
- Sitagliptin Impurity 167 (CAS 1840966-95-1)
Recommended Standards
- Enzalutamide Impurity 33 (CAS 934600-95-0)
- Methyl 3-(Trifluoromethyl)benzoate (CAS 2557-13-3)
- N-hydroxy-3-(trifluoromethyl)benzimidamide (CAS 40067-80-9)
- Methyl 4-trifluoromethylbenzoate (CAS 2967-66-0)
- Proparacaine Impurity 24 (CAS 2815508-81-5)
- Clindamycin Impurity 87 (CAS CATO-C4X-134187)
- Estradiol Impurity 51 (CAS 165609-57-4)
- (S)-2-Amino-4-((4-chlorobenzyl)amino)-1-(piperidin-1-yl)butan-1-one dihydrochloride (CAS 697797-51-6)
- 2-Propenoic acid, 2-methyl-, methyl ester, polymer with ethyl 2-propenoate and 2-oxiranylmethyl 2-methyl-2-propenoate (CAS 25153-49-5)
- 4-[(1s)-1-hydroxyethyl]phenol (CAS 93781-59-0)
- Trospium Impurity 8 (CAS CATO-C4X-20388)
- N-(2-Morpholinophenyl)-1-((3-(trifluoromethyl)phenyl)sulfonyl)piperidine-4-carboxamide (CAS 796082-31-0)
- 4-Bromo-2,5-dichlorobenzonitrile (CAS 1349717-20-9)
- Peptide Impurity 13 (CAS CATO-CPTD788813)
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