Sitagliptin Impurity 133 CAS CATO-C4X-1144133
| CAS No. | CATO-C4X-1144133 |
| Molecular Formula | C17H15F6N5O2 |
| Molecular Weight | 435.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Sitagliptin Impurity 133 (CAS CATO-C4X-1144133, C17H15F6N5O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C17H15F6N5O2, Sitagliptin Impurity 133 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 435.32 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H15F6N5O2 |
| Molecular Weight | 435.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Sitagliptin Standards
- Sitagliptin impurity 114 (CAS CATO-C4X-1144114)
- Sitagliptin Impurity 130 (CAS CATO-C4X-1144130)
- Sitagliptin Impurity 74 (CAS 3056-18-6)
- Sitagliptin impurity 112 (CAS CATO-C4X-1144112)
- Sitagliptin impurity 29 (CAS 2088771-61-1)
- Sitagliptin Tablets EP Impurity FP-B (CAS 2805078-75-3)
- Sitagliptin Impurity 88 (CAS CATO-C4X-114488)
- Sitagliptin Impurity 11 (CAS 1379666-94-0)
Recommended Standards
- tert-Butyl (2-((tert-butoxycarbonyl)oxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate (CAS 2919580-51-9)
- 4-(4,6-Diphenyl-1,3,5-triazin-2-yl)phenylboronic Acid Pinacol Ester (CAS 1219956-23-6)
- N-[(1E)-(2-Phenylhydrazin-1-ylidene)methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide (CAS 338394-11-9)
- 3-(4,6-Diphenyl-1,3,5-triazin-2-yl)phenylboronic Acid Pinacol Ester (CAS 1269508-31-7)
- Atovaquone EP Impurity D (CAS 129700-41-0)
- Baricitinib Impurity 97 (CAS CATO-C4X-226097)
- Famotidine Impurity 53 (CAS CATO-C4X-139253)
- 3-(1H-Benzo[d]imidazol-5-yl)prop-2-en-1-ol (CAS 192717-20-7)
- 2,6-Dimethylpyrimidin-4-yl acetate (CAS 1823935-40-5)
- 5-Bromo-2-(1-methylcyclopropyl)pyrimidin-4(3H)-one (CAS 1511721-31-5)
- Benzyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate hydrochloride (CAS 930782-91-5)
- 4-(Methylamino)nicotinic acid (CAS 1075-09-8)
- 2,2':6',2'':6'',2'''-Quaterpyridine (CAS 4392-83-0)
- Peptide 438 (CAS CATO-CPTD788438)
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