Sitagliptin impurity 29 CAS 2088771-61-1
| CAS No. | 2088771-61-1 |
| Molecular Formula | C16H13F6N5O2 |
| Molecular Weight | 421.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Sitagliptin impurity 29 (CAS 2088771-61-1), a pharmacopoeial impurity reference standard (molecular formula C16H13F6N5O2, MW 421.30 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Sitagliptin impurity 29 (C16H13F6N5O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Sitagliptin impurity 29 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H13F6N5O2 |
| Molecular Weight | 421.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Sitagliptin Standards
- Sitagliptin impurity 112 (CAS CATO-C4X-1144112)
- Sitagliptin Tablets EP Impurity FP-B (CAS 2805078-75-3)
- Sitagliptin Impurity 88 (CAS CATO-C4X-114488)
- Sitagliptin Impurity 130 (CAS CATO-C4X-1144130)
- Sitagliptin Impurity 10 (CAS 1253056-01-7)
- Sitagliptin EP Impurity A (CAS 823817-55-6)
- Sitagliptin Impurity 116 (CAS 945261-50-7)
- Sitagliptin Impurity 156 (CAS 945261-49-4)
Recommended Standards
- Vismodegib (CAS 879085-55-9)
- 6-Bromo-3-(4-tert-butylbenzenesulfonyl)-2H-chromen-2-one (CAS 865656-27-5)
- 4-Bromo-1-methyl-2-phenyl-5-(tosylmethyl)-1,2-dihydro-3H-pyrazol-3-one (CAS 1023502-23-9)
- 3-[(2,4-Dichlorophenyl)methoxy]-N'-(pyridine-2-carboximidoyl)thiophene-2-carbohydrazide (CAS 339009-53-9)
- Revefenacin Impurity 19 (CAS 187741-66-8)
- Atogepant Impurity 34 (CAS 1456803-29-4)
- Bictegravir Impurity 10(2R,5S,13aS) (CAS CATO-C4X-218110)
- 2-Chloro-1-[3-(2-chloroacetyl)phenyl]ethan-1-one (CAS 1713-16-2)
- 8-PErfluorodecyloctane (CAS 93454-70-7)
- 1-Bromo-3-chloro-2-fluoro-5-nitrobenzene (CAS 1330583-70-4)
- Ethyl cyclopentylalaninate (CAS 1526797-59-0)
- 7-Ethoxy-4-hydroxy-6-nitroquinoline-3-carbonitrile (CAS 214476-08-1)
- 2-bromo-5-cyclopropoxypyridine-4-carbonitrile (CAS 1243349-09-8)
- Des-Val23-Tirzepatide (CAS CATO-CPTD788950)
Why CATO?
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