Atovaquone EP Impurity D CAS 129700-41-0
| CAS No. | 129700-41-0 |
| Molecular Formula | C23H21ClO3 |
| Molecular Weight | 380.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Atovaquone EP Impurity D (CAS 129700-41-0) is a certified pharmaceutical impurity reference standard with the molecular formula C23H21ClO3 and a molecular weight of 380.86 g/mol.
The molecular framework of Atovaquone EP Impurity D (C23H21ClO3) is characterized by a steroid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Atovaquone EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H21ClO3 |
| Molecular Weight | 380.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
Related Atovaquone Standards
- cis-Atovaquone-d5 (contains 10% trans isomer) (CAS 1217612-80-0)
- Atovaquone-d5 (CAS 1329792-63-3)
- Atovaquone EP Impurity B (RC A) (CAS 137732-39-9)
- Atovaquone (CAS 95233-18-4)
- Atovaquone EP Impurity A (CAS 2517583-91-2)
- Atovaquone EP Impurity C (CAS 1809464-27-4)
- Atovaquone Impurity 9 (CAS 1100053-58-4)
- Atovaquone Impurity 1 (CAS 49708-81-8)
Recommended Standards
- Nafamostat impurity 75 (CAS 2623-40-7)
- Chlorotrianisene (CAS 569-57-3)
- 5-Bromo-8-(dibromomethyl)quinoxaline (CAS 2101944-49-2)
- 2-Chloro-N-((1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)methyl)-N-phenylbenzamide (CAS 1160245-41-9)
- Baloxavir Impurity 21 (CAS 1985607-68-8)
- Roxadustat Impurity 76 (CAS 74717-81-0)
- Ribavirin Impurity 34 (CAS CATO-C4X-141334)
- 3-((Ethylamino)methyl)-6-methoxy-2-methylquinolin-4(1H)-one (CAS 65273-89-4)
- 5-Amino-N-(4-chloro-phenyl)-2-morpholin-4-yl-benzenesulfonamide (CAS 327072-90-2)
- 1-(Pyridin-2-yl) propan-2-amine (CAS 51038-40-5)
- 5-(2,5-Dimethylfuran-3-yl)isoxazol-3-amine (CAS 1494164-04-3)
- N-(4-Bromophenyl)-N'-ethyl urea (CAS 82745-18-4)
- 4-(Benzyloxy)piperidine (CAS 76716-51-3)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
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