Sitagliptin impurity 141 CAS CATO-C4X-1144141
| CAS No. | CATO-C4X-1144141 |
| Molecular Formula | C6H11F3N4O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Sitagliptin impurity 141 (CAS CATO-C4X-1144141, C6H11F3N4O2C2HF3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Sitagliptin impurity 141 (C6H11F3N4O2C2HF3O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H11F3N4O2 C2HF3O2 |
| Molecular Weight | 342.20 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Sitagliptin Standards
- Sitagliptin Impurity 17 (CAS 1036273-20-7)
- Sitagliptin Impurity 966 (CAS 1151240-88-8)
- Sitagliptin Impurity 14 (CAS 1151240-91-3)
- Sitagliptin Impurity 12 HCl (CAS 1151240-91-3（free base）)
- Sitagliptin Impurity 77 (CAS 1152439-73-0)
- Sitagliptin Impurity 97 (CAS 1169707-29-2)
- Sitagliptin Tablets EP Impurity FP-E HCl (CAS 1204818-19-8)
- Sitagliptin Impurity 15 (CAS 1217809-78-3)
Recommended Standards
- Topiroxostat Impurity 63 (CAS 445218-61-1)
- Cefcapene Impurity 81 (CAS CATO-C4X-182481)
- Budesonide Impurity 77 (CAS CATO-C4X-138977)
- 2-(1H-pyrazol-1-ylmethyl)piperidine (CAS 1249393-90-5)
- Tert-butyl (s)-3-(3-fluorobenzamido)piperidine-1-carboxylate (CAS 1349702-38-0)
- (S)-2-Amino-N-(3-bromobenzyl)-N-cyclopropyl-3-methylbutanamide (CAS 1354000-42-2)
- 6-Amino-2-oxohexanoic acid (CAS 10606-14-1)
- 4-(Ethylthio)phenol (CAS 1195-46-6)
- 1-(3-Chlorophenyl)prop-2-en-1-amine (CAS 1260831-38-6)
- Des-Pro-Pro-Tirzepatide (CAS CATO-CPTD788696)
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