Methotrexate Impurity 23 CAS CATO-C4X-115423
| CAS No. | CATO-C4X-115423 |
| Molecular Formula | C13H15N3O6 |
| Molecular Weight | 309.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Methotrexate Impurity 23 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 309.27 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Methotrexate Impurity 23 (CAS CATO-C4X-115423), a pharmacopoeial impurity reference standard (molecular formula C13H15N3O6, MW 309.27 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H15N3O6 |
| Molecular Weight | 309.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Methotrexate Standards
- Methotrexate impurity 48 (CAS CATO-C4X-115448)
- Methotrexate Impurity 41 (CAS 101810-76-8)
- Methotrexate impurity 7 (CAS CATO-C4X-115447)
- Methotrexate Impurity 76 (CAS CATO-C4X-115476)
- Methotrexate Impurity 74 (CAS CATO-C4X-115474)
- Methotrexate Impurity 75 (CAS CATO-C4X-115475)
- Methotrexate Impurity 70 (CAS CATO-C4X-115470)
- Methotrexate Impurity 77 (CAS CATO-C4X-115477)
Recommended Standards
- 4,4-Dimethoxy-2-[(3-nitrophenyl)methylene]-3-oxo-butanoic Acid Methyl Ester 67448-15-1 Methyl-4,4-dimethoxy-2-(3-nitrobenzylidene)-acetoacetate (CAS 67448-15-1)
- Fructose-glutamic Acid (CAS 31105-01-8)
- Pomalidomide Impurity 20 (CAS CATO-C4X-135420)
- Ethyl 5-((5-acetyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4,5-dihydroisoxazole-3-carboxylate (CAS 339101-01-8)
- Tocopherol impurity 39 (CAS 51028-70-7)
- Axitinib Impurity 41 (CAS 319462-41-4)
- Brivaracetam Impurity 37 (CAS 2165431-90-1)
- (R)-5-Oxiranylmethoxyquinoline (CAS 145679-40-9)
- N-(2-Methylphenethyl)-4-propoxyaniline (CAS 1040689-20-0)
- 1-(Chloromethyl)-3-iodo-5-methylbenzene (CAS 940099-31-0)
- 6-Chloro-N-methylpyridazin-4-amine (CAS 17645-08-8)
- 5-(tert-Butyl)-2-nitrobenzoic Acid (CAS 60772-71-6)
- N-(2-Fluoro-4-methylphenyl)-3-methylbenzamide (CAS 1038042-42-0)
- Nonapeptide-1 (CAS 158563-45-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com