Methotrexate Impurity 18 CAS CATO-C4X-115418
| CAS No. | CATO-C4X-115418 |
| Molecular Formula | C22H27N9O4 |
| Molecular Weight | 481.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Methotrexate Impurity 18 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Methotrexate Impurity 18 (CAS CATO-C4X-115418) is a certified pharmaceutical impurity reference standard with the molecular formula C22H27N9O4 and a molecular weight of 481.51 g/mol.
Structurally, Methotrexate Impurity 18 (C22H27N9O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 481.51 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Methotrexate Impurity 18 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H27N9O4 |
| Molecular Weight | 481.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 9 |
Related Methotrexate Standards
- Methotrexate Dimethylamide (CAS 71074-44-7)
- Methotrexate impurity N3 (CAS 65148-64-3)
- Methotrexate EP Impurity J (CAS 34378-65-9)
- Methotrexate Impurity 61 (CAS 65148-63-2)
- Methotrexate impurity 50 (CAS CATO-C4X-115450)
- Methotrexate impurity 53 (CAS CATO-C4X-115453)
- Methotrexate-d (CAS 432545-60-3)
- Methotrexate Impurity 28 (CAS 5939-37-7)
Recommended Standards
- GSK-598809, >98% (HPLC) (CAS 863680-45-9)
- Fmoc-4-(2-fluorophenyl)-L-phenylalanine (CAS 352525-27-0)
- Belumosudil Impurity 15 (CAS CATO-C4X-298815)
- distamycin A (CAS 636-47-5)
- Nintedanib Impurity 24 (CAS CATO-C4X-181424)
- Dapoxetine Impurity 63 (CAS CATO-C4X-143963)
- Indobufen Impurity 39 (CAS 13048-83-4)
- 2,4-Dimethyl-1,3-dioxolane (CAS 3390-12-3)
- 2-(2-Bromo-3-chloro-6-fluorophenyl)-1,3-dioxolane (CAS 2221812-07-1)
- 5-Chloro-2-(pyrrolidin-1-yl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 2096994-83-9)
- 2-(Piperazin-1-ylmethyl)-3,4-dihydroquinazolin-4-one (CAS 725690-23-3)
- 5-Phenyl-3H-thieno[2,3-d]pyrimidin-4-one (CAS 35978-39-3)
- WIKI4 (CAS 838818-26-1)
- Stresscopin-Related Peptide (human) (CAS 348626-74-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com