Hydrochlorothiazide impurity 47 CAS CATO-C4X-117747

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-117747
Molecular FormulaC6H7ClN2O5S2
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Hydrochlorothiazide impurity 47 CAS CATO-C4X-117747 chemical structure

Description

The occurrence of Hydrochlorothiazide impurity 47 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies Hydrochlorothiazide impurity 47 (CAS CATO-C4X-117747), a pharmacopoeial impurity reference standard (molecular formula C6H7ClN2O5S2C6H8ClN3O4S2HCl, MW 608.88 g/mol) used for the identification and quantification of trace impurities in APIs.

Hydrochlorothiazide impurity 47 (C6H7ClN2O5S2C6H8ClN3O4S2HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC6H7ClN2O5S2 C6H8ClN3O4S2 2*HCl
Molecular Weight608.88 g/mol
Purity97%+
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Halogen ContentCl-containing
Nitrogen Atoms5
Sulfur Atoms4

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