Hydrochlorothiazide Impurity 1 CAS 133-74-4
| CAS No. | 133-74-4 |
| Molecular Formula | C6H6ClNO3S |
| Molecular Weight | 207.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Hydrochlorothiazide Impurity 1 is closely related to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Hydrochlorothiazide Impurity 1 (CAS 133-74-4), a certified reference material (molecular formula C6H6ClNO3S, MW 207.63 g/mol) for analytical method development and quality control.
Owing to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Hydrochlorothiazide Impurity 1 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 207.63 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Hydrochlorothiazide Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H6ClNO3S |
| Molecular Weight | 207.63 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Hydrochlorothiazide Standards
- Hydrochlorothiazide Impurity 40 (CAS CATO-C4X-117740)
- Hydrochlorothiazide Impurity 41 (CAS CATO-C4X-117741)
- Hydrochlorothiazide Impurity N17 (CAS 1954-94-5)
- Hydrochlorothiazide Impurity N8 (CAS 4140-83-4)
- Hydrochlorothiazide Impurity 23 (CAS 19477-32-8)
- Hydrochlorothiazide Impurity (CAS 360-81-6)
- Hydrochlorothiazide Impurity 35 (CAS CATO-C4X-117735)
- Hydrochlorothiazide Impurity 36 (CAS CATO-C4X-117736)
Recommended Standards
- 4-chloro-2-hydroxybenzene-1-sulfonamide (CAS 1243372-63-5)
- 1,1,2-Trichloro-1,2,2-trimethyldisilane (CAS 13528-88-6)
- 1214354-55-8 Pyridine, 2-chloro-6-(4-fluorophenyl)- (CAS 1214354-55-8)
- 2-(3-Chloro-5-fluorophenyl)pyridine (CAS 1379364-97-2)
- 3-[(3-methyl-2,5-dioxoimidazolidin-1-yl)methyl]benzonitrile (CAS 1042646-00-3)
- Benzo[4,5]imidazo[1,2-a]pyrimidin-4-ol (CAS 1087654-58-7)
- 5-Fluorobenzo[b]thiophen-3-amine (CAS 1007455-48-2)
- Avanafil Impurity 147 (CAS CATO-C4X-1118147)
- 3-Amino-2-chlorobenzoic Acid (CAS 108679-71-6)
- 2-(5-Amino-3-((methylsulfonyl)methyl)-1h-pyrazol-1-yl)ethan-1-ol (CAS 1339058-55-7)
- 2-Fluoro-3-(trifluoromethoxy)aniline (CAS 1159512-64-7)
- 63136-64-1 4-Chloro-2,5,7-trimethylquinoline DTXSID40489638 (CAS 63136-64-1)
- 5-Bromo-2-(sec-butyl)pyrimidin-4(3h)-one (CAS 1517357-08-2)
- Peptide 434 (CAS CATO-CPTD788434)
Why CATO?
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