Hydrochlorothiazide EP Impurity B CAS 121-30-2
| CAS No. | 121-30-2 |
| Molecular Formula | C6H8ClN3O4S2 |
| Molecular Weight | 285.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Hydrochlorothiazide EP Impurity B.
As a process- or degradation-related impurity, Hydrochlorothiazide EP Impurity B (CAS 121-30-2, C6H8ClN3O4S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Hydrochlorothiazide EP Impurity B (C6H8ClN3O4S2) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Hydrochlorothiazide EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H8ClN3O4S2 |
| Molecular Weight | 285.73 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related Hydrochlorothiazide Standards
- Hydrochlorothiazide impurity 44 (CAS CATO-C4X-117744)
- Hydrochlorothiazide Impurity 52 (CAS CATO-C4X-117752)
- Hydrochlorothiazide Impurity 13 (CAS 99418-26-5)
- Hydrochlorothiazide Impurity 22 (CAS 90794-87-9)
- Hydrochlorothiazide Impurity 20 (CAS 82205-98-9)
- Hydrochlorothiazide Impurity 56 (CAS CATO-C4X-117756)
- Hydrochlorothiazide EP Impurity A (CAS 58-94-6)
- Hydrochlorothiazide (CAS 58-93-5)
Recommended Standards
- 1-(2-chloro-4-nitrophenyl)-4-(2-hydroxyethyl)piperazine 2-[4-(2-Chloro-4-nitrophenyl)piperazin-1-yl]ethanol 2-[4-(2-chloro-4-nitrophenyl)piperazin-1-yl]-ethanol 312269-35-5 (CAS 312269-35-5)
- Methyl 1-(2-chloro-4-fluorobenzyl)piperidine-4-carboxylate (CAS 1057273-64-9)
- Tert-butyl 2-chloro-4-methoxy-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate (CAS 2410119-23-0)
- Methyl 1-(3-chloro-4-fluorobenzyl)piperidine-4-carboxylate (CAS 1443309-24-7)
- Calcitriol impurity 56 (CAS CATO-C4X-151056)
- Upacicalcet Sodium Impurity 5 (CAS CATO-C4X-33925)
- Stigmasterol Impurity 4 (CAS 7212-91-1)
- [4-(Fluoromethyl)phenyl]boronic acid (CAS 301699-41-2)
- 3-(4-Amino-3,5-dimethyl-1H-pyrazol-1-yl)tetrahydrothiophene 1,1-dioxide (CAS 1156111-10-2)
- 7-Nitro-N,N-dipropylbenzo[c][1,2,5]oxadiazol-4-amine (CAS 74400-48-9)
- 2-Iodoquinolin-4-ol (CAS 5652-12-0)
- (3-(Isopentyloxy)phenyl)(methyl)sulfane (CAS 1443311-75-8)
- 2-(3-Amino-4-bromo-1h-pyrazol-1-yl)acetonitrile (CAS 1250104-10-9)
- Allo-D-Ile12-Tirzepatide (CAS CATO-CPTD788963)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com