Eltrombopag Impurity 46 CAS CATO-C4X-119846
| CAS No. | CATO-C4X-119846 |
| Molecular Formula | C26H20N2O6 |
| Molecular Weight | 456.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Eltrombopag Impurity 46.
As a process- or degradation-related impurity, Eltrombopag Impurity 46 (CAS CATO-C4X-119846, C26H20N2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Eltrombopag Impurity 46 (C26H20N2O6) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 18.0, corresponding to approximately 18 ring(s) or double-bond equivalent(s). With a molecular weight of 456.45 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H20N2O6 |
| Molecular Weight | 456.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Eltrombopag Standards
- Eltrombopag Impurity 93 (CAS CATO-C4X-119893)
- Eltrombopag Methyl Ester (CAS 1246929-01-0)
- Eltrombopag Impurity 24 (CAS 1437383-35-1)
- Eltrombopag Impurity 45 (CAS CATO-C4X-119845)
- Eltrombopag N-Oxide Impurity (CAS CATO-C4X-11981)
- Eltrombopag Impurity 155 (CAS CATO-C4X-1198155)
- Eltrombopag Impurity 120 (CAS CATO-C4X-1198120)
- Eltrombopag Impurity 7 (CAS 1428987-69-2)
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- 5-Methyl-1H-benzo[d]imidazole-6-carbaldehyde (CAS 61587-92-6)
- 2-[(3-methoxyphenyl)methyl]azepane hydrochloride (CAS 2060031-33-4)
- Semaglutide Impurity 4 (CAS CATO-C4X-22264)
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