Cefotiam Impurity 21 CAS CATO-C4X-120421
| CAS No. | CATO-C4X-120421 |
| Molecular Formula | C23H27N11O5S4 |
| Molecular Weight | 665.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cefotiam Impurity 21.
Cefotiam Impurity 21 (CAS CATO-C4X-120421) is a certified pharmaceutical impurity reference standard with the molecular formula C23H27N11O5S4 and a molecular weight of 665.79 g/mol.
Structurally, Cefotiam Impurity 21 (C23H27N11O5S4) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 665.79 g/mol, it falls into the high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Cefotiam Impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H27N11O5S4 |
| Molecular Weight | 665.79 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 11 |
| Sulfur Atoms | 4 |
Related Cefotiam Standards
- Cefotiam Impurity 46 (CAS CATO-C4X-120446)
- Cefotiam Impurity 13 (CAS 759418-62-7)
- Cefotiam Impurity 36 (CAS 95761-91-4)
- Cefotiam Impurity 33 (CAS CATO-C4X-120433)
- Cefotiam Impurity 47 (CAS CATO-C4X-120447)
- Cefotiam Impurity 18 (CAS CATO-C4X-120418)
- Cefotiam Impurity 27 (CAS CATO-C4X-120427)
- Cefotiam Impurity 52 (CAS CATO-C4X-120452)
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