Posaconazole impurity 231 CAS CATO-C4X-1208231
| CAS No. | CATO-C4X-1208231 |
| Molecular Formula | C37H42F2N8O4 |
| Molecular Weight | 700.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Posaconazole impurity 231 (CAS CATO-C4X-1208231, C37H42F2N8O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C37H42F2N8O4, Posaconazole impurity 231 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 700.78 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C37H42F2N8O4 |
| Molecular Weight | 700.78 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Posaconazole Standards
- Posaconazole (CAS 171228-49-2)
- Posaconazole Impurity 12(S,S,R,R) (CAS 2243785-97-7)
- Posaconazole Impurity 13(R,R,R,R) (CAS 170985-61-2)
- Posaconazole Impurity 14(S,R,R,R) (CAS 213381-05-6)
- Posaconazole Impurity 15(S,S,S,S) (CAS 1246391-73-0)
- Posaconazole Impurity 157 (CAS CATO-C4X-1208157)
- Posaconazole Impurity 16(S,R,S,S) (CAS 213381-02-3)
- Posaconazole Impurity 17(R,R,R,S) (CAS 171228-51-6)
Recommended Standards
- Posaconazole Impurity 23(S,R,S,R) (CAS 213381-04-5)
- Posaconazole Impurity 24(S,S,S,R) (CAS 2243785-98-8)
- Posaconazole impurity 222 (CAS CATO-C4X-1208222)
- Posaconazole Impurity 54(R,S,S,S) (CAS 2243785-96-6)
- Ibrutinib Impurity 146 (CAS CATO-C4X-1064146)
- Vonoprazan Impurity 274 (CAS 2514724-36-6)
- Benzbromarone Impurity 22 (CAS CATO-C4X-225022)
- 873006-01-0 2-Iodo-4-(trifluoromethyl)benzaldehyde DTXSID00731605 (CAS 873006-01-0)
- 2,3-Dichloro-DL-phenylalanine (CAS 110300-04-4)
- Ethyl 2-(3-chloro-2-fluoro-phenoxy)acetate (CAS 1443305-09-6)
- 898775-92-3 1-(4-Bromo-3-fluorophenyl)-3-(4-methoxyphenyl)propan-1-one DTXSID30644279 (CAS 898775-92-3)
- 5-Bromo-2-(2,6-difluoro-4-(trifluoromethyl)phenoxy)-4-fluoroaniline (CAS 2244088-78-4)
- 4-Methyl-2-tosylisoquinolin-1(2H)-one (CAS 918867-79-5)
- Peptide Impurity 26 (CAS 1350456-66-4)
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