Gimeracil Impurity 8 CAS CATO-C4X-12148
| CAS No. | CATO-C4X-12148 |
| Molecular Formula | C14H14Cl2N2O5 |
| Molecular Weight | 361.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Gimeracil Impurity 8.
CATO supplies Gimeracil Impurity 8 (CAS CATO-C4X-12148), a pharmacopoeial impurity reference standard (molecular formula C14H14Cl2N2O5, MW 361.18 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Gimeracil Impurity 8 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 361.18 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H14Cl2N2O5 |
| Molecular Weight | 361.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Gimeracil Standards
- Gimeracil Impurity 7 (CAS 17902-24-8)
- Gimeracil impurity 10 (CAS CATO-C4X-121410)
- Gimeracil impurity 11 (CAS 149143-67-9)
- Gimeracil impurity 12 (CAS 149143-68-0)
- Gimeracil Impurity 1 (CAS CATO-C4X-12141)
- Gimeracil Impurity N1 (CAS 1227600-22-7)
- Gimeracil (CAS 103766-25-2)
- Gimeracil Impurity 5 (CAS 89942-45-0)
Recommended Standards
- Hydrochlorothiazide Impurity 26 (CAS CATO-C4X-117726)
- 2-(Bromomethyl)-4,5-dihydroxy-6-methoxytetrahydro-2H-pyran-3-yl benzoate (CAS 10368-81-7)
- tert-Butyl (5-bromo-4-(trifluoromethyl)thiazol-2-yl)(methyl)carbamate (CAS 2806011-23-2)
- n-Cycloheptyl-4-fluoro-2-iodobenzamide (CAS 1208838-15-6)
- Mitiglinide Calcium Impurity 17 (CAS 70925-10-9)
- Atogepant Impurity 62 (CAS CATO-C4X-328562)
- Atorvastatin Impurity 140 (CAS CATO-C4X-1132140)
- 3`,4`-Dichloropropiophenone (CAS 6582-42-9)
- 3-Iodo-2,4-dimethylaniline (CAS 4102-51-6)
- 4-Chloro-5-(cyclobutylmethoxy)pyridazin-3(2H)-one (CAS 1346697-59-3)
- 7-(4-(Tert-butyl)phenyl)-7-oxoheptanoic acid (CAS 898791-45-2)
- (R,S)-Norcotinine-pyridyl-d4 (CAS 1020719-70-3)
- 1-(4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazin-1-yl)ethanone (CAS 1206594-13-9)
- D-γ-Glu20-Side-Tirzepatide (CAS CATO-CPTD788929)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com