Anastrozole Impurity 28 CAS CATO-C4X-123928
| CAS No. | CATO-C4X-123928 |
| Molecular Formula | C12H16Br2 |
| Molecular Weight | 320.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Anastrozole Impurity 28 (CAS CATO-C4X-123928, C12H16Br2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Anastrozole Impurity 28 (C12H16Br2) contains bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 320.06 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H16Br2 |
| Molecular Weight | 320.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
Related Anastrozole Standards
- Anastrozole Impurity 36 (CAS CATO-C4X-123936)
- Anastrozole Impurity 14 (CAS 1338800-82-0)
- Anastrozole Impurity 8 (CAS CATO-C4X-12398)
- Anastrozole Impurity 9 (CAS 120512-03-0)
- Anastrozole Impurity 16 (CAS 120512-04-1)
- Anastrozole Impurity 15 (CAS 2469244-33-3)
- Anastrozole Impurity 39 (CAS CATO-C4X-123939)
- Anastrozole Diacid (CAS 1338800-81-9)
Recommended Standards
- Methyl 6-fluoro-3-iodo-1H-indazole-4-carboxylate (CAS 885521-81-3)
- (3-((5-Ethoxy-5-oxopentyl)oxy)-2,4,6-trifluorophenyl)boronic acid (CAS 1150114-31-0)
- 8-Bromo-2-(trifluoromethyl)quinoline-4-carboxylic acid (CAS 587886-03-1)
- 2-(Difluoromethoxy)-4-iodonaphthalene (CAS 1261627-73-9)
- Tofacitinib Impurity 166 DiHCl (CAS 2106832-55-5)
- Rizatriptan EP Impurity D (CAS CATO-C4X-17526)
- Alfacalcidol Impurity 6 (CAS CATO-C4X-13936)
- 1-(Pyridin-2-yl)pentan-1-amine (CAS 94032-53-8)
- 12-Hydroxyhexadecanoic acid (CAS 83646-62-2)
- 4-(Hydroxymethyl)azepan-4-ol (CAS 884586-69-0)
- 2-Methyl-4-[2-(trimethylsilyl)ethynyl]-1,3-thiazole (CAS 329203-85-2)
- 5-Ethyl-4-(1-(phenylsulfonyl)ethyl)-1-(4-(trifluoromethoxy)phenyl)-1,3-dihydro-2H-imidazol-2-one (CAS 477848-59-2)
- (2R,3S,4S)-2-[3,4-Bis(phenylmethoxy)phenyl]-3,4-dihydro-3,5,7-tris(phenylmethoxy)-2H-1-benzopyran-4-ol (CAS 574749-29-4)
- Tirzepatide Impurity 23 X TFA Salt (CAS CATO-C4X-324023)
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