Quetiapine Impurity 57 CAS CATO-C4X-124457
| CAS No. | CATO-C4X-124457 |
| Molecular Formula | C12H27N2O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Quetiapine Impurity 57 is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Quetiapine Impurity 57 (CAS CATO-C4X-124457, C12H27N2O4Cl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Quetiapine Impurity 57 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 298.81 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H27N2O4 Cl |
| Molecular Weight | 298.81 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 0.0 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Quetiapine Standards
- Quetiapine Carboxylate Impurity (CAS 1011758-00-1)
- Quetiapine EP Impurity P (CAS 1011758-03-4)
- Quetiapine EP Impurity P Hemifumarate (CAS 1011758-03-4（free base）)
- Quetiapine Impurity 56 (CAS 1015-89-0)
- Quetiapine Impurity N3 (CAS 102893-57-2)
- Quetiapine-d8 HemifumarateDISCONTINUED. Please see Q510002. (CAS 1031703-36-2)
- Quetiapine EP Impurity H (CAS 1076199-40-0)
- Quetiapine (CAS 111974-69-7)
Recommended Standards
- Naltrexone impurity 52 (CAS CATO-C4X-147552)
- Oseltamivir Impurity 106 (CAS CATO-C4X-1720106)
- Trametinib Impurity 19 (CAS CATO-C4X-278219)
- [2-(1-Cyano-1-methylethyl)phenyl]boronic acid (CAS 2377606-63-6)
- 2-[2-bromo-4-(ethylsulfanyl)phenyl]acetic acid (CAS 1823084-85-0)
- Ibrutinib (CAS 936563-96-1)
- 2-(3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)acetic Acid (CAS 106660-11-1)
- 5-(Trifluoromethyl)isoxazol-3(2H)-one (CAS 388091-41-6)
- {[3-(4-bromophenoxy)propyl]sulfanyl}carbonitrile (CAS 7494-06-6)
- Semaglutide impurity 85 (CAS CATO-C4X-222685)
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