Quetiapine impurity 72 CAS CATO-C4X-124472
| CAS No. | CATO-C4X-124472 |
| Molecular Formula | C12H27N2O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Quetiapine impurity 72 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Quetiapine impurity 72 (CAS CATO-C4X-124472, C12H27N2O4Cl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Quetiapine impurity 72 (C12H27N2O4Cl) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H27N2O4 Cl |
| Molecular Weight | 298.81 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 0.0 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Quetiapine Standards
- Quetiapine Carboxylate Impurity (CAS 1011758-00-1)
- Quetiapine EP Impurity P (CAS 1011758-03-4)
- Quetiapine EP Impurity P Hemifumarate (CAS 1011758-03-4（free base）)
- Quetiapine Impurity 56 (CAS 1015-89-0)
- Quetiapine Impurity N3 (CAS 102893-57-2)
- Quetiapine-d8 HemifumarateDISCONTINUED. Please see Q510002. (CAS 1031703-36-2)
- Quetiapine EP Impurity H (CAS 1076199-40-0)
- Quetiapine (CAS 111974-69-7)
Recommended Standards
- Atrasentan Impurity 148 (CAS 1058350-27-8)
- Tizanidine Impurity 58 (CAS CATO-C4X-144558)
- 【货号停用，见C4X-127024】Cefaclor Impurity 18 (CAS CATO-C4X-127018)
- 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,5-difluorobenzoic acid (CAS 2243515-56-0)
- Epothilone B (CAS 152044-54-7)
- Methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzoate (CAS 1810790-95-4)
- Methyl 2,3,4-Tri-O-benzyl-β-D-glucuronic Acid, Benzyl Ester (CAS 4356-83-6)
- 3-(Tert-butyl)-4-chloro-1H-pyrazole-5-carboxylic acid (CAS 1344266-29-0)
- Lacidipine Impurity 25 (CAS CATO-C4X-167125)
- Peptide 435 (CAS CATO-CPTD788435)
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