Ixazomib Impurity 20 CAS CATO-C4X-126720
| CAS No. | CATO-C4X-126720 |
| Molecular Formula | C18H20BCl2NO8 |
| Molecular Weight | 460.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ixazomib Impurity 20.
As a process- or degradation-related impurity, Ixazomib Impurity 20 (CAS CATO-C4X-126720, C18H20BCl2NO8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ixazomib Impurity 20 (C18H20BCl2NO8) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H20BCl2NO8 |
| Molecular Weight | 460.07 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ixazomib Standards
- Ixazomib Impurity 35 (CAS CATO-C4X-126735)
- Ixazomib Impurity 86 (CAS CATO-C4X-126786)
- Ixazomib Impurity 87 (CAS CATO-C4X-126787)
- Ixazomib Impurity 46 (CAS CATO-C4X-126746)
- Ixazomib Impurity 47 (CAS CATO-C4X-126747)
- Ixazomib Impurity 48 (CAS CATO-C4X-126748)
- Ixazomib Impurity 71 (CAS 2920604-29-9)
- Ixazomib Impurity 75 (CAS CATO-C4X-126775)
Recommended Standards
- 42573-57-9 2-(p-Methoxystyryl)-4,6-bis(trichloromethyl)-1,3,5-triazine 1,3,5-Triazine, 2-(2-(4-methoxyphenyl)ethenyl)-4,6-bis(trichloromethyl)- 2,4-Bis(trichloromethyl)-6-p-methoxystyryl-s-triazine EINECS 255-893-1 (CAS 42573-57-9)
- 4-Bromo-3-nitro-1,1'-biphenyl (CAS 27701-66-2)
- 2H-Perfluoro-2-decenoic Acid 13C2 (1,2-13C2) (CAS 872398-79-3)
- 1,8-Diiodoanthracene-9,10-dione (CAS 30877-00-0)
- Bilastine Impurity 16 (CAS 2411093-91-7)
- Clenbuterol Impurity 23 (CAS CATO-C4X-199323)
- Iguratimod Impurity 22 (CAS CATO-C4X-182622)
- 5-Hydroxyhexan-2-one (CAS 56745-61-0)
- 5-(Trifluoromethoxy)pyridin-2-amine dihydrochloride (CAS 1707602-50-3)
- (S)-2-(3-(difluoromethyl)-4-fluoro-5-(trifluoromethyl)phenyl)pyrrolidine (CAS 1447005-57-3)
- N,N-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-tetrazol-5-amine (CAS 338417-26-8)
- (9-(Dibenzo[b,d]furan-2-yl)-9H-carbazol-3-yl)diphenylphosphine oxide (CAS 1437305-42-4)
- Coliforms in Food (CAS CATO-CQCM102284)
- Peptide T (CAS 106362-32-7)
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