Ixazomib Impurity 46 CAS CATO-C4X-126746
| CAS No. | CATO-C4X-126746 |
| Molecular Formula | C20H28BCl3N2O4 |
| Molecular Weight | 477.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ixazomib Impurity 46.
Ixazomib Impurity 46 (CAS CATO-C4X-126746) is a certified pharmaceutical impurity reference standard with the molecular formula C20H28BCl3N2O4 and a molecular weight of 477.62 g/mol.
Structurally, Ixazomib Impurity 46 (C20H28BCl3N2O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.5, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 477.62 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H28BCl3N2O4 |
| Molecular Weight | 477.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Ixazomib Standards
- Ixazomib Impurity 47 (CAS CATO-C4X-126747)
- Ixazomib Impurity 48 (CAS CATO-C4X-126748)
- Ixazomib Impurity 86 (CAS CATO-C4X-126786)
- Ixazomib Impurity 87 (CAS CATO-C4X-126787)
- Ixazomib Impurity 20 (CAS CATO-C4X-126720)
- Ixazomib Impurity 35 (CAS CATO-C4X-126735)
- Ixazomib Impurity N1 (CAS 1201903-02-7)
- Ixazomib Impurity 72 (CAS CATO-C4X-126772)
Recommended Standards
- S,S',S''-((2,4,6-Trioxo-1,3,5-triazinane-1,3,5-triyl)tris(propane-3,1-diyl)) triethanethioate (CAS 76486-41-4)
- N-(benzo[d]thiazol-2-yl)-2-((3-cyano-6-methyl-4-(thiophen-3-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)thio)acetamide (CAS 340813-94-7)
- N-((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-4-methylbenzenesulfonamide (CAS 200944-17-8)
- Boc-D-Homocys(Trt)-OH (CAS 1301706-43-3)
- Loratadine Impurity N9 (CAS 107256-32-6)
- Procymidone Impurity 43 (CAS 169327-83-7)
- Ozenoxacin Impurity 58 (CAS CATO-C4X-279658)
- 5-(Oxan-4-yl)-1,2-oxazol-3-amine (CAS 1229454-64-1)
- 1-(3-Chloropyridin-4-yl)ethanone (CAS 78790-82-6)
- N-(2,5-difluorobenzyl)-2-(1H-1,2,4-triazol-1-yl)acetamide (CAS 866149-89-5)
- 4-Fluoro-3-[(6-fluoroimidazo[1,2-a]pyridine-3-carbonyl)amino]benzoic acid methyl ester (CAS 2088941-82-4)
- n-Isopropyl-1,3-dimethyl-1h-pyrazolo[3,4-b]pyridin-5-amine (CAS 1157781-23-1)
- n-Cyclopropyl-3-(o-tolyl)cyclobutan-1-amine hydrochloride (CAS 1354954-29-2)
- Semaglutide impurity 36 (CAS CATO-C4X-222636)
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