Ixazomib Impurity 6 CAS CATO-C4X-12676
| CAS No. | CATO-C4X-12676 |
| Molecular Formula | C14H18Cl2N2O3 |
| Molecular Weight | 333.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Ixazomib Impurity 6 (CAS CATO-C4X-12676, C14H18Cl2N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ixazomib Impurity 6 (C14H18Cl2N2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ixazomib Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H18Cl2N2O3 |
| Molecular Weight | 333.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Ixazomib Standards
- Ixazomib Impurity 5 (CAS CATO-C4X-12675)
- Ixazomib Impurity 62 (CAS CATO-C4X-126762)
- Ixazomib Impurity 4 (CAS CATO-C4X-12674)
- Ixazomib Impurity 55 (CAS CATO-C4X-126755)
- Ixazomib Impurity 7 (CAS CATO-C4X-12677)
- Ixazomib Impurity 8 (CAS CATO-C4X-12678)
- Ixazomib Impurity 73 (CAS CATO-C4X-126773)
- Ixazomib Impurity 43 (CAS CATO-C4X-126743)
Recommended Standards
- [4-(4-Bromobutoxy)phenyl]-phenylmethanone (CAS 101308-54-7)
- N-(2-(1H-Indol-3-yl)ethyl)-3,4-dichlorobenzamide (CAS 22174-00-1)
- 4-(4-Bromophenyl)-5-(methylsulfonyl)thiazol-2-amine (CAS 1017782-62-5)
- Ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]isothiazole-3-carboxylate (CAS 936923-42-1)
- Eldecalcitol Impurity 25 (CAS CATO-C4X-214025)
- Baloxavir Marboxil Impurity 182 (CAS CATO-C4X-2108182)
- Ixazomib Impurity 84 (CAS CATO-C4X-126784)
- 3-Amino-3-methyl-1-butanol Hydrochloride (CAS 357185-97-8)
- (2-(Isopentylthio)-1-(4-methylbenzyl)-1H-imidazol-5-yl)methanol (CAS 941891-49-2)
- 4-Bromo-1-(2,6-dichlorophenyl)-1H-pyrazole (CAS 1215205-65-4)
- Ethyl (3-thioxo-3H-1,2,4-dithiazol-5-yl)carbamate (CAS 36289-42-6)
- (1-Azepan-1-ylcyclohexyl)methylamine (CAS 891373-47-0)
- Lincomycin Hydrochloride Monohydrate (CAS 7179-49-9)
- Semaglutide Impurity 5 (CAS 23406-82-8)
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