Ixazomib Impurity 7 CAS CATO-C4X-12677
| CAS No. | CATO-C4X-12677 |
| Molecular Formula | C14H18Cl2N2O4 |
| Molecular Weight | 349.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ixazomib Impurity 7.
CATO supplies Ixazomib Impurity 7 (CAS CATO-C4X-12677), a pharmacopoeial impurity reference standard (molecular formula C14H18Cl2N2O4, MW 349.21 g/mol) used for the identification and quantification of trace impurities in APIs.
Ixazomib Impurity 7 (C14H18Cl2N2O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ixazomib Impurity 7 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H18Cl2N2O4 |
| Molecular Weight | 349.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Ixazomib Standards
- Ixazomib Impurity 55 (CAS CATO-C4X-126755)
- Ixazomib Impurity 8 (CAS CATO-C4X-12678)
- Ixazomib Impurity 62 (CAS CATO-C4X-126762)
- Ixazomib Impurity 77 (CAS CATO-C4X-126777)
- Ixazomib (CAS 1072833-77-2)
- Ixazomib Impurity 3 (CAS CATO-C4X-12673)
- Ixazomib Impurity 81 (CAS CATO-C4X-126781)
- Ixazomib-13C2,15N (CAS CATO-C4X-126764)
Recommended Standards
- tert-butyl 3-(3-iodo-1-bicyclo[1.1.1]pentanyl)azetidine-1-carboxylate (CAS 2375261-02-0)
- Phenytoin Impurity 17 (CAS CATO-C4X-186417)
- N,N-bis(2,4-dinitrophenyl)amine (CAS 2908-76-1)
- 2-(4-Bromophenyl)-3-phenylimidazo[1,2-a]pyridine (CAS 1027074-52-7)
- Flomoxef Impurity 13 (CAS CATO-C4X-138213)
- Cisapride Impurity 3 (CAS 105249-06-7)
- Canagliflozin Impurity 112 (CAS 1132832-76-8)
- 5,6-Dibromo-7-methyl-1H,2H,3H-imidazo[4,5-b]pyridin-2-one (CAS 2169997-51-5)
- 6-Methyl-2-morpholin-4-yl-pyrimidine-4-carboxylic acid (CAS 873450-14-7)
- 1-(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)-2,2,2-trifluoroethan-1-amine (CAS 2167515-85-5)
- 2-(Furan-2-yl)-4-methyl-6-(methylsulfanyl)pyrimidine-5-carboxylic acid (CAS 941096-30-6)
- Oseltamivir Impurity 132 (CAS 162252-43-9)
- 3-(1,3-Benzodioxole-5-Carbonyl)-5-Fluoro-1-[(2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Pyrimidine-2,4-Dione (CAS 74234-11-0)
- Pancreatic Polypeptide (bovine) (CAS 179986-89-1)
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