Ixazomib Impurity 81 CAS CATO-C4X-126781
| CAS No. | CATO-C4X-126781 |
| Molecular Formula | C15H18Cl2N2O4 |
| Molecular Weight | 361.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ixazomib Impurity 81 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Ixazomib Impurity 81 (CAS CATO-C4X-126781), a pharmacopoeial impurity reference standard (molecular formula C15H18Cl2N2O4, MW 361.22 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Ixazomib Impurity 81 (C15H18Cl2N2O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ixazomib Impurity 81 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H18Cl2N2O4 |
| Molecular Weight | 361.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Ixazomib Standards
- Ixazomib (CAS 1072833-77-2)
- Ixazomib Impurity 3 (CAS CATO-C4X-12673)
- Ixazomib Impurity 77 (CAS CATO-C4X-126777)
- Ixazomib-13C2,15N (CAS CATO-C4X-126764)
- Ixazomib Impurity 55 (CAS CATO-C4X-126755)
- Ixazomib Impurity 7 (CAS CATO-C4X-12677)
- Ixazomib Impurity 8 (CAS CATO-C4X-12678)
- Ixazomib Impurity 62 (CAS CATO-C4X-126762)
Recommended Standards
- Ziprasidone Impurity 15 (CAS CATO-C4X-124015)
- 2-[(2-Bromoacetyl)amino]-N-ethyl-N-phenylbenzamide (CAS 1138442-64-4)
- (R)-N-Boc-|A-(iodomethyl)benzeneethanamine 293305-69-8 N-[(1R)-1-(Iodomethyl)-2-phenylethyl]carbamic Acid 1,1-Dimethylethyl Ester (CAS 293305-69-8)
- 3-[(2-Bromoacetyl)amino]-N-ethyl-N-phenylbenzamide (CAS 1138442-97-3)
- Nalmefene Impurity 10 (CAS 144265-45-2)
- Pranoprofen Impurity 37 (CAS CATO-C4X-181137)
- Perampanel Impurity 14 (CAS 4341-02-0)
- 2-(Propylamino)pyridine-3-sulfonamide (CAS 1247456-99-0)
- n-[4-(butan-2-yl)phenyl]-2-chloroacetamide (CAS 20331-26-4)
- Aripiprazole EP Impurity G (CAS 1797986-18-5)
- rel-((1S,3R)-4,4-Difluorospiro[2.2]pentan-1-yl)methanamine hydrochloride (CAS 2838097-92-8)
- 3-hydroxybutan-2-one (CAS 52217-02-4)
- 6-(Piperazin-1-yl)pyridazin-3-ol hydrochloride (CAS 1103508-29-7)
- Semaglutide impurity 44 (CAS CATO-C4X-222644)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com