Nafamostat Impurity 49 HCl CAS CATO-C4X-133249
| CAS No. | CATO-C4X-133249 |
| Molecular Formula | C19H16N4O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 384.82 g/mol gives Nafamostat Impurity 49 HCl distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Nafamostat Impurity 49 HCl (CAS CATO-C4X-133249, C19H16N4O3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Nafamostat Impurity 49 HCl (C19H16N4O3HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H16N4O3 HCl |
| Molecular Weight | 384.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Nafamostat Standards
- Nafamostat Impurity 61 (CAS 1026613-65-9)
- Nafamostat impurity 110 (CAS 107490-62-0)
- Nafamostat Impurity 65 (CAS 107490-62-0（free base）)
- Nafamostat Impurity N3 (CAS 115325-88-7)
- Nafamostat Impurity 26 (CAS 1192026-58-6)
- Nafamostat Impurity 63 (CAS 121714-82-7)
- Nafamostat Impurity 37 (CAS 122228-09-5)
- Nafamostat Impurity 35 (CAS 130200-58-7)
Recommended Standards
- Carboxyamidotriazole Impurity 1 (CAS 203202-66-8)
- Clopidogrel Impurity 10 (CAS 43189-20-4)
- Cefcapene Impurity 2 (CAS 105889-80-3)
- Nitrendipine Impurity 13 (CAS 104765-27-7)
- n-(1h-Indazol-5-yl)-3-oxobutanamide (CAS 6023-70-7)
- L-371,257 (CAS 162042-44-6)
- 8-Bromo-6-fluoro-2-methyl-2,4-dihydro-1,4-benzoxazin-3-one (CAS 1267046-92-3)
- 1-(1H-Indol-3-ylmethyl)piperidin-4-aminedihydrochloride (CAS 1158785-32-0)
- 2-[(2-methylcyclohexyl)oxy]acetonitrile (CAS 1016866-31-1)
- Des-[Oct-γ-Glu-AEEA-AEEA]-Semaglutide (CAS CATO-C4X-2226112)
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