Levofloxacin Impurity 81 CAS CATO-C4X-137181
| CAS No. | CATO-C4X-137181 |
| Molecular Formula | C17H20FN3O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Levofloxacin Impurity 81 (CAS CATO-C4X-137181) is a certified pharmaceutical impurity reference standard with the molecular formula C17H20FN3O2HCl and a molecular weight of 353.82 g/mol.
Levofloxacin Impurity 81 (C17H20FN3O2HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Levofloxacin Impurity 81 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H20FN3O2 HCl |
| Molecular Weight | 353.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Levofloxacin Standards
- Levofloxacin (CAS 100986-85-4)
- Levofloxacin R-Isomer（Levofloxacin EP Impurity A） (CAS 100986-86-5)
- Levofloxacin EP Impurity F (CAS 100986-89-8)
- Levofloxacin Impurity 35 (CAS 1012310-27-8)
- Levofloxacin Impurity 51 (CAS 1026952-91-9)
- Levofloxacin Impurity N27 (CAS 1036016-10-0)
- Levofloxacin Impurity 100 (CAS 104600-15-9)
- Levofloxacin Impurity 101 (CAS 105804-40-8)
Recommended Standards
- Oseltamivir Impurity 91 (CAS CATO-C4X-172091)
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- Pregabalin Impurity 46 (CAS 1101167-84-3)
- 2,5-Dichloro-3-fluorophenol (CAS 1394927-62-8)
- 2-Bromo-6-fluoro-4-methylphenylboronic acid (CAS 1451391-47-1)
- 5-(2-Chloroacetamido)benzene-1,3-dicarboxylic acid (CAS 61389-11-5)
- 1-BRomo-2-methylcyclohex-1-ene (CAS 99747-75-8)
- 1-[(tert-butoxy)carbonyl]-2-(methoxymethyl)piperidine-2-carboxylic acid (CAS 2044713-23-5)
- 3-(5-Pyrimidinyl)phenol (CAS 69491-50-5)
- Peptide Impurity 40 (CAS CATO-CPTD788840)
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