S-Adenosyl-L-Methionine Impurity 8 CAS CATO-C4X-13818
| CAS No. | CATO-C4X-13818 |
| Molecular Formula | C12H18N5O3S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies S-Adenosyl-L-Methionine Impurity 8 (CAS CATO-C4X-13818), a pharmacopoeial impurity reference standard (molecular formula C12H18N5O3SI, MW 439.27 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, S-Adenosyl-L-Methionine Impurity 8 (C12H18N5O3SI) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, iodine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 439.27 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), S-Adenosyl-L-Methionine Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H18N5O3S I |
| Molecular Weight | 439.27 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | I-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related S Standards
- S-Adenosyl-L-Methionine Impurity 19 (CAS 13484-65-6)
- S-Adenosyl-D-methionine (CAS 14031-35-7)
- S-Adenosyl-L-Methionine Impurity 17 (CAS 2095880-61-6)
- ADENOSYL-L-METHIONINE CHLORIDE, S- (CAS 24346-00-7)
- S-Adenosyl-L-Methionine (CAS 29908-03-0)
- S-Adenosyl-L-Methionine Impurity 18 (CAS 37063-35-7)
- S-Adenosyl-L-Methionine Impurity 10 (CAS 4229-50-9)
- S-Adenosyl-L-methionine 4-methylbenzenesulfonic acid bis(4-methylbenzenesulfonate) salt (CAS 52248-04-1)
Recommended Standards
- Vilanterol Impurity 72 (CAS CATO-C4X-193572)
- Thioctic acid Impurity 35 (CAS 74903-53-0)
- Epinastine Impurity 44 Fumarate (CAS 127785-96-0)
- (D-Arg1,D-Trp7·9,Leu11)-Substance P (CAS 91224-37-2)
- Rebamipide impurity 22 (CAS 212502-72-2)
- 4-Bromooxazolo[4,5-c]pyridine (CAS 1936080-23-7)
- 2-(Chloromethyl)-5-(3-methylphenyl)-1,3,4-oxadiazole (CAS 24023-73-2)
- (3,3-Dimethylcyclohexyl)methanamine hydrochloride (CAS 212382-66-6)
- Methyl 3,3,3-trifluoro-2-hydroxy-2-(1H-indol-3-yl)propanoate (CAS 114125-58-5)
- Semaglutide impurity 83 (CAS CATO-C4X-222683)
Why CATO?
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