S-Adenosyl-L-Methionine Impurity 18 CAS 37063-35-7
| CAS No. | 37063-35-7 |
| Molecular Formula | C10H11N5O6P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
S-Adenosyl-L-Methionine Impurity 18 (CAS 37063-35-7) is a certified pharmaceutical impurity reference standard with the molecular formula C10H11N5O6PNa and a molecular weight of 351.19 g/mol.
The molecular framework of S-Adenosyl-L-Methionine Impurity 18 (C10H11N5O6PNa) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), S-Adenosyl-L-Methionine Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H11N5O6P Na |
| Molecular Weight | 351.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Nitrogen Atoms | 5 |
Related S Standards
- S-Adenosyl-L-Methionine Impurity 19 (CAS 13484-65-6)
- S-Adenosyl-D-methionine (CAS 14031-35-7)
- S-Adenosyl-L-Methionine Impurity 17 (CAS 2095880-61-6)
- ADENOSYL-L-METHIONINE CHLORIDE, S- (CAS 24346-00-7)
- S-Adenosyl-L-Methionine (CAS 29908-03-0)
- S-Adenosyl-L-Methionine Impurity 10 (CAS 4229-50-9)
- S-Adenosyl-L-methionine 4-methylbenzenesulfonic acid bis(4-methylbenzenesulfonate) salt (CAS 52248-04-1)
- S-(5')-Adenosyl-3-thiopropylamine (CAS 53186-57-5)
Recommended Standards
- Pazopanib Impurity 42 (CAS 1226500-01-1)
- Bosutinib 4-Chloro 7-Chloropropoxy Impurity (CAS 214470-68-5)
- Hydrocortisone Impurity 31 (CAS 10184-70-0)
- 6-(3-Amino-4-methylphenyl)pyridazin-3-ol (CAS 1030563-11-1)
- Methyl 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carboxylate (CAS 1558276-67-7)
- 3,5-Diethyl 6-{[(E)-[(dimethylamino)methylidene]amino]amino}-2-oxo-1,2-dihydropyridine-3,5-dicarboxylate (CAS 321432-01-3)
- 2-(2-Chlorobenzo[d]oxazol-4-yl)acetic acid (CAS 1803794-81-1)
- H-D-Tyr-OEt.HCl (CAS 23234-43-7)
- 9,10,16-Trihydroxyhexadecanoic acid (CAS 6949-98-0)
- Peptide Impurity 34 (CAS 21282-09-7)
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