Azelastine impurity 66 CAS CATO-C4X-139666
| CAS No. | CATO-C4X-139666 |
| Molecular Formula | C23H26ClN3O |
| Molecular Weight | 395.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Azelastine impurity 66.
Azelastine impurity 66 (CAS CATO-C4X-139666) is a certified pharmaceutical impurity reference standard with the molecular formula C23H26ClN3O and a molecular weight of 395.93 g/mol.
Azelastine impurity 66 (C23H26ClN3O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Azelastine impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H26ClN3O |
| Molecular Weight | 395.93 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Azelastine Standards
- Azelastine Impurity 72 (CAS CATO-C4X-139672)
- (S)-Azelastine N-Oxide (Mixture of Diastereomers) (CAS 1346617-06-8)
- (R)-Azelastine N-Oxide (Mixture of Diastereomers) (CAS 1346617-18-2)
- Azelastine USP Related Compound F (CAS 640279-88-5)
- Azelastine-13C,d3 N-Oxide (Mixture of Diastereomers) (CAS 1346602-76-3)
- Azelastine-d3 (CAS 758637-88-6)
- Azelastine-13C,d3 (CAS 1217019-80-1)
- (R)-Azelastine (CAS 143228-84-6)
Recommended Standards
- N-(3-Chlorophenyl)-2-((3-ethyl-6-methyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide (CAS 851409-63-7)
- Perfluoroamyl Iodide (CAS 638-79-9)
- 8-Chloro-11-(4-(dimethylamino)phenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one (CAS 946387-29-7)
- 4-({[(4-chlorophenyl)methyl]sulfanyl}methyl)-2-phenyl-6-(pyrrolidin-1-yl)pyrimidine (CAS 338961-72-1)
- Cefadroxil Impurity 17 (CAS 700-63-0)
- Voriconazole EP Impurity E(Voriconazole Related Compound F) (CAS 5872-08-2)
- Vecuronium Bromide EP Impurity D (CAS 73319-30-9)
- 2-Benzylidene-1-phenylbutane-1,3-dione (CAS 25354-72-7)
- 2-(Pyrimidin-2-yl)ethan-1-amine (CAS 89464-80-2)
- 3-(5-((3-Chlorobenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)pyridine (CAS 618426-63-4)
- 4-Iodo-2-methylpyrimidine-5-carbonitrile (CAS 1876691-51-8)
- 1,4,6,8-Tetramethylfuro[2,3-h]quinolin-2(1H)-one (CAS 174022-38-9)
- 1-(2-Nitro-4-(trifluoromethyl)phenyl)guanidine (CAS 216016-28-3)
- Cholecystokinin Octapeptide (desulfated) (H-2070.0005) (CAS 198483-36-2)
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