Azelastine Impurity 72 CAS CATO-C4X-139672
| CAS No. | CATO-C4X-139672 |
| Molecular Formula | C22H22ClN3O2 |
| Molecular Weight | 395.88 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Azelastine Impurity 72 (CAS CATO-C4X-139672, C22H22ClN3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Azelastine Impurity 72 (C22H22ClN3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H22ClN3O2 |
| Molecular Weight | 395.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Azelastine Standards
- Azelastine impurity 66 (CAS CATO-C4X-139666)
- (S)-Azelastine N-Oxide (Mixture of Diastereomers) (CAS 1346617-06-8)
- (R)-Azelastine N-Oxide (Mixture of Diastereomers) (CAS 1346617-18-2)
- Azelastine USP Related Compound F (CAS 640279-88-5)
- Azelastine-13C,d3 N-Oxide (Mixture of Diastereomers) (CAS 1346602-76-3)
- Azelastine-d3 (CAS 758637-88-6)
- Azelastine-13C,d3 (CAS 1217019-80-1)
- (R)-Azelastine (CAS 143228-84-6)
Recommended Standards
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- (1-(3-Chloro-4-methylphenyl)-1H-1,2,3-triazol-4-yl)(4-(4-methylpiperazin-1-yl)phenyl)methanone (CAS 477847-90-8)
- Palbociclib Impurity N38 HCl (CAS 571191-15-6（free base）)
- Granisetron EP Impurity H (CAS 4498-67-3)
- Erlotinib Impurity 39 (CAS CATO-C4X-106939)
- trans-4-((((Benzyloxy)carbonyl)amino)methyl)cyclohexane-1-carboxylic acid (CAS 27687-12-3)
- Ethyl 4,5,6,7-tetrahydro-1H-indazole-4-carboxylate (CAS 1251015-04-9)
- N'-[(1E)-(Thiophen-2-yl)methylidene]quinoline-6-carbohydrazide (CAS 866018-92-0)
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