Loratadine Impurity 13 CAS CATO-C4X-142613
| CAS No. | CATO-C4X-142613 |
| Molecular Formula | C20H23ClN2O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Loratadine Impurity 13 (C20H23ClN2OCH2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 388.89 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Loratadine Impurity 13 (CAS CATO-C4X-142613, C20H23ClN2OCH2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H23ClN2O CH2O2 |
| Molecular Weight | 388.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loratadine Standards
- Loratadine EP Impurity D (CAS 100643-71-8)
- Loratadine-d5 (CAS 1020719-57-6)
- Loratadine Impurity N9 (CAS 107256-32-6)
- Loratadine Impurity 53 (CAS 107285-30-3)
- Loratadine Impurity 28 (CAS 1073332-71-4)
- Loratadine Epoxide (CAS 1189694-51-6)
- Loratadine Methanone Impurity (CAS 119770-60-4)
- Loratadine EP Impurity F (CAS 125743-80-8)
Recommended Standards
- Abiraterone Impurity N5 (CAS 93830-58-1)
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- 5-(Naphthalen-2-ylsulfanyl)-1,2,3-thiadiazole (CAS 400083-63-8)
- Ethyl 4-bromo-5-chloro-8-methylquinoline-3-carboxylate (CAS 1242260-75-8)
- Neuropeptide Y (1-24) amide (human, rat) (CAS 131448-51-6)
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