Loratadine EP Impurity D CAS 100643-71-8
| CAS No. | 100643-71-8 |
| Molecular Formula | C19H19ClN2 |
| Molecular Weight | 310.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Loratadine EP Impurity D (CAS 100643-71-8) is a certified pharmaceutical impurity reference standard with the molecular formula C19H19ClN2 and a molecular weight of 310.82 g/mol.
The molecular framework of Loratadine EP Impurity D (C19H19ClN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Loratadine EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H19ClN2 |
| Molecular Weight | 310.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loratadine Standards
- Loratadine Impurity 76 (CAS CATO-C4X-142676)
- Loratadine Impurity 53 (CAS 107285-30-3)
- Loratadine Impurity 30 (CAS 1346600-30-3)
- Loratadine EP Impurity G (CAS 38092-89-6)
- Loratadine Impurity 94 (CAS CATO-C4X-142694)
- Loratadine Impurity 77 (CAS 170727-68-1)
- Loratadine Impurity 28 (CAS 3964-81-6)
- Loratadine impurity 87 (CAS 130642-54-5)
Recommended Standards
- Rupatadine Impurity 36 (CAS 169253-15-0)
- Desloratadine EP Impurity B (CAS 183198-49-4)
- 8-(4-Chlorophenoxy)-2-methylene-octanoic Acid Ethyl Ester 82258-37-5 Ethyl 8-(4-Chlorophenoxy)-2-methylen-octanoate (CAS 82258-37-5)
- Desloratadine Impurity 21 (CAS 1346600-61-0)
- Apremilast Impurity 23 (CAS 2077897-94-8)
- Melitracen Impurity 13 (CAS 71264-79-4)
- Letermovir impurity 137 (CAS CATO-C4X-2915137)
- 2-Picoline-5-boronic acid hydrate (CAS 1072952-30-7)
- [1,1'-Biphenyl]-3-ylmethanol (CAS 69605-90-9)
- 2,6-Dibromo-9,10-di-1-naphthalenylanthracene (CAS 914306-89-1)
- Upadacitinib Impurity 163 (CAS CATO-C4X-2405163)
- Erlotinib Impurity 146 (CAS CATO-C4X-1069146)
- Methyl 6-Bromo-5-methylindole-3-acetate (CAS 2097800-44-5)
- Semaglutide impurity 61 (CAS CATO-C4X-222661)
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