Iopamidol Impurity 45 CAS CATO-C4X-145045
| CAS No. | CATO-C4X-145045 |
| Molecular Formula | C13H12ClI3N2O6 |
| Molecular Weight | 708.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Iopamidol Impurity 45 (CAS CATO-C4X-145045, C13H12ClI3N2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Iopamidol Impurity 45 (C13H12ClI3N2O6) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/iodine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H12ClI3N2O6 |
| Molecular Weight | 708.41 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/I-containing |
| Nitrogen Atoms | 2 |
Related Iopamidol Standards
- Iopamidol Impurity 44 (CAS CATO-C4X-145044)
- Iopamidol Impurity 52 (CAS 60166-91-8)
- Iopamidol EP Impurity A (CAS 60166-98-5)
- Iopamidol EP Impurity D (CAS 87932-11-4)
- Iopamidol Impurity 33 (CAS CATO-C4X-145033)
- Iopamidol Impurity 49 (CAS CATO-C4X-145049)
- Iopamidol Impurity 46 (CAS CATO-C4X-145046)
- Iopamidol Impurity 43 (CAS CATO-C4X-145043)
Recommended Standards
- 3-Acetylpyridine adenine dinucleotide (disodium) (CAS 102029-93-6)
- [4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecyl)phenyl] diphenylphosphine (CAS 462996-04-9)
- Dichloro[9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene]Cobalt(II) (CAS 898807-69-7)
- H-Pro-Arg-AMC (CAS 546103-85-9)
- Iopamidol Impurity 18 (CAS 130930-29-9)
- Ledipasvir Impurity 25 (CAS CATO-C4X-331325)
- Diflorasone impurity 2 (CAS CATO-C4X-24802)
- 4-Chloro-5-ethyl-6-methyl-2-(pentan-3-yl)pyrimidine (CAS 1248762-46-0)
- 4-Iodo-1-isobutyl-1H-pyrazol-3-amine (CAS 1354706-80-1)
- 3-(4-Fluorotetrahydro-2H-pyran-4-yl)benzoic acid (CAS 1556049-81-0)
- 4-Ethynyl-5-fluoro-2-methoxypyridine (CAS 1211584-33-6)
- 5-(4-Chlorophenyl)-4-(3-methylphenyl)-4h-1,2,4-triazole-3-thiol (CAS 592537-79-6)
- 5-Bromo-2-chloro-4-fluorobenzenesulfonyl chloride (CAS 1123307-06-1)
- [y-Glu3]-Semaglutide Impurity 135 (CAS CATO-C4X-2226135)
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