Phenylephrine Impurity 77 CAS CATO-C4X-146777
| CAS No. | CATO-C4X-146777 |
| Molecular Formula | C8H8Br2O2 |
| Molecular Weight | 295.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Phenylephrine Impurity 77 (CAS CATO-C4X-146777), a pharmacopoeial impurity reference standard (molecular formula C8H8Br2O2, MW 295.96 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Phenylephrine Impurity 77 (C8H8Br2O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 295.96 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8Br2O2 |
| Molecular Weight | 295.96 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
Related Phenylephrine Standards
- Phenylephrine Impurity 76 (CAS CATO-C4X-146776)
- Phenylephrine Impurity 75 (CAS CATO-C4X-146775)
- Phenylephrine Impurity 63 (CAS CATO-C4X-146763)
- Phenylephrine Impurity 64 (CAS CATO-C4X-146764)
- Phenylephrine Impurity 104 (CAS CATO-C4X-1467104)
- Phenylephrine Impurity 13 (CAS 830346-80-0)
- Phenylephrine Impurity 18 (Mixture of Diastereomers) (CAS 1217525-08-0)
- Phenylephrine Impurity 19 (CAS 915278-80-7)
Recommended Standards
- 2-Bromo-1-(3-bromopropyl)-4-fluorobenzene (CAS 1057678-47-3)
- 3,5-Dibromo-4-ethoxypyridin-2-amine (CAS 89694-75-7)
- 1-Bromo-2-(3-bromopropyl)-4-fluorobenzene (CAS 1057678-49-5)
- 2,6-dibromo-4-(2-hydroxyethyl)phenol (CAS 303009-05-4)
- N-Nitroso Ranolazine Impurity 14 (CAS CATO-C4X-102614)
- Epinephrine Impurity 66 (CAS CATO-C4X-184966)
- Sunitinib Impurity N1 (CAS 2377533-92-9)
- N-Acetyl Retigabine (CAS 229970-68-7)
- 2-Fluoro-3-methyl-5-(trifluoromethyl)benzamide (CAS 2384846-77-7)
- Lactic Acid Ethyl Carbonate (CAS 5700-72-1)
- Paeoniflorigenone (CAS 80454-42-8)
- (4-Chloro-2-nitrophenyl)hydrazine (CAS 54454-57-8)
- tert-butyl N-[2-[3-[2-[2-[3-[[2-(tert-butoxycarbonylamino)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-2-oxo-ethyl]carbamate (CAS 2110448-96-7)
- Insulin Degludec Impurity 2 (CAS CATO-C4X-21572)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com