Ketoconazole Impurity 19 CAS CATO-C4X-147219
| CAS No. | CATO-C4X-147219 |
| Molecular Formula | C13H7Cl3O3 |
| Molecular Weight | 317.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Ketoconazole Impurity 19 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 317.55 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Ketoconazole Impurity 19 (CAS CATO-C4X-147219) is a certified pharmaceutical impurity reference standard with the molecular formula C13H7Cl3O3 and a molecular weight of 317.55 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ketoconazole Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H7Cl3O3 |
| Molecular Weight | 317.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Ketoconazole Standards
- Ketoconazole Impurity 22 (CAS CATO-C4X-147222)
- Ketoconazole Impurity 25 (CAS CATO-C4X-147225)
- Ketoconazole Impurity 10 (CAS 61441-65-4)
- Ketoconazole Impurity 11 (CAS 84682-23-5)
- Ketoconazole Impurity 13 (and enantiomer) (CAS 61397-58-8)
- Ketoconazole Impurity 14 (CAS 170210-49-8)
- Ketoconazole Impurity 35 (CAS CATO-C4X-147235)
- Ketoconazole Impurity N15 (CAS 170210-42-1)
Recommended Standards
- N-Hexadecylaniline (CAS 4439-42-3)
- Ethyl Stearate-d5 (CAS 1216808-22-8)
- N,N-dioctylaniline (CAS 3007-75-8)
- 2-(2-Bromo-4-fluorophenoxy)ethane-1-sulfonyl chloride (CAS 1339226-45-7)
- Budesonide impurity 45 (CAS 3517-49-5)
- Iopamidol Impurity 56 (CAS CATO-C4X-145056)
- Amoxicillin impurity 105 (CAS CATO-C4X-1148105)
- tert-Butyl 3-methylazetidine-1-carboxylate (CAS 1314984-00-3)
- 2-Methoxy-5-nitro-6-picoline (CAS 5467-69-6)
- tert-Butyl (R)-2-(3-methylbenzyl)piperazine-1-carboxylate (CAS 1240587-90-9)
- N-(3-bromobenzyl)isobutyramide (CAS 932942-99-9)
- 1-Methyl-5-phenyl-1H-pyrazol-4-ol (CAS 95884-16-5)
- Methyl (5-(but-3-en-1-ylthio)-1H-benzo[d]imidazol-2-yl)carbamate (CAS 58840-93-0)
- Fibrinogen-Binding Inhibitor Peptide (CAS 89105-94-2)
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