Ketoconazole Impurity 22 CAS CATO-C4X-147222
| CAS No. | CATO-C4X-147222 |
| Molecular Formula | C14H9Cl3O2 |
| Molecular Weight | 315.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Ketoconazole Impurity 22 (CAS CATO-C4X-147222, C14H9Cl3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Ketoconazole Impurity 22 (C14H9Cl3O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 315.58 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H9Cl3O2 |
| Molecular Weight | 315.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Ketoconazole Standards
- Ketoconazole Impurity 25 (CAS CATO-C4X-147225)
- Ketoconazole Impurity 19 (CAS CATO-C4X-147219)
- Ketoconazole Impurity 10 (CAS 61441-65-4)
- Ketoconazole Impurity 11 (CAS 84682-23-5)
- Ketoconazole Impurity 13 (and enantiomer) (CAS 61397-58-8)
- Ketoconazole Impurity 14 (CAS 170210-49-8)
- Ketoconazole Impurity 35 (CAS CATO-C4X-147235)
- Ketoconazole Impurity N15 (CAS 170210-42-1)
Recommended Standards
- Indometacin Impurity 24 (CAS 99508-25-5)
- N-(3-Amino-4-chlorophenyl)-3,5-dichlorobenzamide (CAS 926238-20-2)
- Triclocarban (CAS 101-20-2)
- N-(3-Amino-4-chlorophenyl)-2,4-dichlorobenzamide (CAS 926242-00-4)
- Isothiazole Impurity 3 (CAS 252004-29-8)
- Amphotericin B Impurity 24 (CAS CATO-C4X-184424)
- Cefadroxil USP Related Compound I (CAS 147103-94-4)
- ISODRIN (CAS 465-73-6)
- Ethyl 2-(3-(3-fluoro-4-methylbenzoyl)-4-hydroxy-5-oxo-2-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-1-yl)-4-methylthiazole-5-carboxylate (CAS 618072-71-2)
- Methyl 3'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1'-bi(bicyclo[1.1.1]pentane)]-3-carboxylate (CAS 2826263-80-1)
- 6-Chloro-8-nitro-2H-benzo[b][1,4]oxazin-3(4H)-one (CAS 870064-73-6)
- 4'-Methoxy-[1,1'-biphenyl]-2-amine (CAS 38089-03-1)
- 3-Hydroxy-N-(2-oxotetrahydrofuran-3-yl)pentanamide (CAS 148433-24-3)
- D-Ile12-Tirzepatide (CAS CATO-CPTD788921)
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