Ketoconazole impurity 27 CAS CATO-C4X-147227
| CAS No. | CATO-C4X-147227 |
| Molecular Formula | C24H25Cl2N5O4 |
| Molecular Weight | 518.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Ketoconazole impurity 27 (CAS CATO-C4X-147227), a pharmacopoeial impurity reference standard (molecular formula C24H25Cl2N5O4, MW 518.39 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Ketoconazole impurity 27 (C24H25Cl2N5O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 518.39 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H25Cl2N5O4 |
| Molecular Weight | 518.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Ketoconazole Standards
- Ketoconazole EP Impurity A (and enantiomer) (CAS 254912-63-5)
- Ketoconazole Impurity 26 (CAS CATO-C4X-147226)
- Ketoconazole EP Impurity C (and enantiomer) (CAS 83374-59-8)
- Ketoconazole (CAS 65277-42-1)
- Ketoconazole-d8 (CAS 1217706-96-1)
- Ketoconazole impurity 32 (CAS CATO-C4X-147232)
- Ketoconazole impurity 33 (CAS CATO-C4X-147233)
- Ketoconazole N-Oxide (and enantiomer) (CAS 254912-65-7)
Recommended Standards
- (S)-6-(5-Bromo-1-((1r,4S)-4-methoxycyclohexyl)-1H-benzo[d]imidazol-2-yl)-1-(3,4-difluorophenyl)piperidin-2-one (CAS 2222964-03-4)
- Avanafil Impurity 118 (CAS CATO-C4X-1118118)
- 9,10[1',2']-Benzenoanthracene-2,3,6,7,14,15-hexacarboxylicacid,9,10-dihydro (CAS 945681-56-1)
- Avanafil Impurity 24 (CAS CATO-C4X-111824)
- Risperidone Impurity 31 (CAS 66698-27-9)
- Cefradine Impurity 17 (CAS CATO-C4X-121517)
- Ambroxol EP Impurity D (CAS 107814-37-9)
- 3-{4-[(2,4-dichlorophenyl)methoxy]phenyl}-1-(thiophene-2-carbonyl)-1H-pyrazole (CAS 477711-58-3)
- tert-Butyl (4-bromofuran-2-yl)carbamate (CAS 1935268-93-1)
- Isoindoline-5,6-diol hydrobromide (CAS 105358-67-6)
- N-[2-(Indol-3-yl-2,4,5,6,7-d5)acetyl]-L-aspartic-15N Acid (CAS 1201012-71-6)
- 1-FLUORO-4-(2-HYDROXYETHYL)BENZENE 2-(4-FLUOROPHENYL)ETHAN-1-OL 2-(4-FLUOROPHENYL)ETHANOL 4-FLUOROPHENYLETHANOL 4-Fluorophenethyl alcohol 7589-27-7 AS00589 OTAVA-BB 1204387 (CAS 7589-27-7)
- 1-Acetyl-3-methylpyrrolidine-3-carboxylic acid (CAS 1342361-74-3)
- Semaglutide Main Chain P29 (CAS 1169630-82-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com